Cytotoxic and anti-diabetic potential, metabolic profiling and studies of (L.) Skeels belonging to family .

LC-HR-MS-coupled metabolic profiling of the methanol extracts from different parts of (L.), which was extensively identified DNA fingerprinting, led to dereplication of 24 compounds. Cytotoxic investigation highlighted both extracts as the most potent, against both MCF-7 and MDA-231 Cell lines, with IC value of 5.86 ± 0.63 µg/ml and against HCT -116 cell line, with IC value of 1.24 ± 0.09 µg/ml, respectively. A molecular docking study was performed on the dereplicated compounds, which highlighted myricetin-3-glucoside (), myricitrin (), reynoutrin () and quercitrin () as the top scoring ligands within the protein active site (FIH-1). Interestingly, the extracts were significant against streptozotocin-induced diabetes in the order of flowers > seeds > leaves with BGL level of 98.9 ± 4.3, 123.2 ± 4.9 and 132.8 ± 5.9 mg/dl, respectively. The study highlights the health benefits of (L.) as a promising cytotoxic source.