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Two new compounds with anti-inflammatory activity from . | LitMetric

Two new compounds with anti-inflammatory activity from .

Nat Prod Res

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Published: February 2022

A new phenolic glycoside, chinenside A (), and a new megastigmane glycoside, chinenionside A (), together with twelve known compounds (), were isolated from the roots of . Their structures were deduced on the basis of extensive spectroscopic analyses and comparison with data reported in the literature. The anti-inflammatory activity in vitro of all 13 phenolic glycosides was evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. The compounds , , and potentially inhibited the productions of nitric oxide (NO), prostaglandin (PEG), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6). Compound (50 μM) showed stronger anti-inflammatory activity than Triptolide (TPL, 20 nm).

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Source
http://dx.doi.org/10.1080/14786419.2020.1843033DOI Listing

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