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Error in Mendelian randomization analysis in "Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma".
Osteoporos Int
December 2024
Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Lifetime asthma incidence is related to age at onset and allergies in western Sweden.
Clin Transl Allergy
December 2024
Department of Internal Medicine and Clinical Nutrition, Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Although asthma is more frequently diagnosed in childhood, a substantial proportion of cases manifests in adulthood. Nonetheless, few studies have comprehensively examined asthma incidence across different ages, genders, and asthma phenotypes. We conducted a retrospective evaluation of asthma incidence from birth to late adulthood, stratified by age, gender, and the presence or absence of allergies.
View Article and Find Full Text PDFPhysical exercise, systemic inflammation and adult-onset asthma: a 12-year follow-up study.
J Asthma
December 2024
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Physical exercise in treatment of asthma is scarcely studied with no clear exercise guidelines for asthmatics. We aimed to investigate the associations between physical exercise frequency, systemic inflammation and asthma control. This has not been previously studied in adult-onset asthma.
View Article and Find Full Text PDFUnspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis.
Front Immunol
December 2024
The Liggins Institute, The University of Auckland, Auckland, New Zealand.
Introduction: Asthma is a heterogeneous condition that is characterized by reversible airway obstruction. Childhood-onset asthma (COA) and adult-onset asthma (AOA) are two prominent asthma subtypes, each with unique etiological factors and prognosis, which suggests the existence of both shared and distinct risk factors.
Methods: Here, we employed a two-sample Mendelian randomization analysis to elucidate the causal association between genes within lung and whole-blood-specific gene regulatory networks (GRNs) and the development of unspecified asthma, COA, and AOA using the Wald ratio method.
Obesity predicts mortality stronger in adult-onset asthma than in age- and sex-matched controls.
Clin Transl Allergy
December 2024
Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden.
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