Close loop system identification techniques have been used to identify the presence of feedback in the firing pattern of thalamic tremor cells recorded in parkinsonian tremor patients.
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Protocol for recording physiological signals from the human cerebellum using electroencephalography.
STAR Protoc
January 2025
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY 10032, USA. Electronic address:
As Purkinje cells of the cerebellum have a very fast firing rate, techniques with high temporal resolution are required to capture cerebellar physiology. Here, we present a protocol to record physiological signals in humans using cerebellar electroencephalography (cEEG). We describe steps for electrode placement and recording.
View Article and Find Full Text PDFBackground: Christianson syndrome (CS) is an x-linked recessive neurodevelopmental and neurodegenerative condition characterized by severe intellectual disability, cerebellar degeneration, ataxia, and epilepsy. Mutations to the gene encoding NHE6 are responsible for CS, and we recently demonstrated that a mutation to the rat gene causes a similar phenotype in the spontaneous rat model, which exhibits cerebellar degeneration with motor dysfunction. In previous work, we used the PhP.
View Article and Find Full Text PDFIntoxication of sheep by in northwestern Argentina.
J Vet Diagn Invest
January 2025
Faculty of Agricultural Sciences, National University of Jujuy, Jujuy, Argentina.
Spontaneous intoxication by was diagnosed in a flock of 300 sheep in Jujuy province, northwestern Argentina, that grazed an area heavily invaded by this plant. The main clinical signs were intention tremors, ataxia, and progressive loss of condition. Autopsy of 2 affected animals revealed loss of body condition.
View Article and Find Full Text PDFArticle Synopsis
- Atypical porcine pestivirus (APPV), linked to congenital tremor A-II in pigs, was first identified in 2015 and has now been found in various regions globally.
- From 2020 to 2024, a study in Russia screened 2630 pig samples from 14 regions, finding APPV in 12 farms with an overall positive rate of 8.8%, indicating its circulation in Russian swine since at least 2020.
- Phylogenetic analysis of the virus revealed high genetic similarities with Hungarian, USA, and South Korean strains, showing considerable variation among Russian isolates, and confirmed successful replication of one strain in cell culture.
Prolonged neurologic symptoms following immune effector cell-associated neurotoxicity syndrome in patients with large B cell lymphoma treated with chimeric antigen receptor-modified T cell therapy.
Transplant Cell Ther
January 2025
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Background: While immune effector cell-associated neurotoxicity syndrome (ICANS) is a well-defined adverse effect associated with chimeric antigen receptor-modified T cell (CAR-T) therapy, some patients develop prolonged neurologic symptoms. Few studies have examined characteristics and outcomes of patients who develop such symptoms.
Objective: To provide an analysis of patients who developed ICANS in a single-center cohort of patients with large B-cell lymphoma (LBCL) who received commercial CAR-T and compare characteristics and outcomes between patients with vs.
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