A pair of novel lipopeptide epimers, sinulariapeptides A () and B (), and a new phthalide glycerol ether () were isolated from the marine algal-associated fungus SCSIO41401, together with three known chromanone derivates (-). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo (OAc)-induced ECD methods. The new compounds - showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC values of 1.3-2.5 μM, and an in silico molecular docking study was also performed.
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