Cystic echinococcosis (CE), a zoonotic disease caused by the larval stage of the tapeworm (), is a worldwide public health problem. (), associated with G1 and G3 genotypes, is endemic with high prevalence in the Mediterranean basin. The parasite's life cycle comprises definitive hosts (canids) and intermediate hosts (ruminants) and can occasionally involve humans. The main aim of this research was to confirm the diagnosis of 13 patients suspected of CE who presented different complications and needed the surgical removal of the cysts. We also wanted to understand and clarify more the diagnosis of echinococcosis in humans. For this purpose, the patients first underwent cyst evaluation by ultrasound (US), immunological analysis, and then total pericystectomy, followed by parasitological, histopathological, and molecular biology examinations of the cysts. US stadiated one CE1, one CE2, eight CE3b, one CE4, and two CE5; immunology evidenced nine positives; histopathology confirmed 11 CE cysts, of which 8 fertile presenting protoscoleces were identified as by molecular biology, genotyped as three G1 and four G3 by neighbor-joining (NJ) phylogenetic tree. In conclusion, the results showed that 11 patients were affected by G1 orG3, and 2 cystic neoformations were of non-parasitic origin.
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http://dx.doi.org/10.3390/pathogens9110907 | DOI Listing |
Vet Med Sci
January 2025
Department of Veterinary Sciences, Salale University, Fiche, Ethiopia.
Cystic echinococcosis (CE) is a cestode infection of significant public health and economic importance. A systematic review and meta-analysis was performed to estimate the pooled prevalence of small ruminant CE and associated risk factors in Ethiopia. The published literature written in English from 01 January 2000 to 30 December 2019 was searched from electronic databases and eligible reports that fulfilled inclusion and exclusion criteria.
View Article and Find Full Text PDFArch Razi Inst
June 2024
College of Health Medical Technique, Al-Bayan University. Baghdad, Iraq.
The present study was conducted from December 2021 to April 2023 at the College of Health and Medical Technologies, Al-Bayan University, in Baghdad province, Iraq, to detect infection in humans by serological methods. Field studies were conducted using 1,500 sera samples from hospitals and private medical laboratories. The sera samples were separated and examined by indirect immunoglobulin G enzyme-linked immunosorbent assays to serologically detect infection.
View Article and Find Full Text PDFParasit Vectors
December 2024
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis and College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Background: Echinococcosis is a zoonotic disease caused by an Echinococcus tapeworm infection. While diagnostic methods for humans often rely on ultrasound imaging and immunodiagnostic techniques, diagnosis in intermediate hosts typically has no widely used diagnostic markers, hampering disease control efforts.
Methods: The differences in serum metabolites of sheep infected with Echinococcus granulosus and a control group were analyzed using ultrahigh-performance liquid chromatography (UHPLC) separation with tandem mass spectrometry (MS/MS) detection.
BMC Mol Cell Biol
December 2024
Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Cystic echinococcosis (CE) is a worldwide zoonotic public health issue. The reasons for this include a lack of specific therapy options, increasing antiparasitic drug resistance, a lack of control strategies, and the absence of an approved vaccine. The aim of the current study is to develop a multiepitope vaccine against CE by in-silico identification and using different Antigen B subunits.
View Article and Find Full Text PDFSci Rep
December 2024
Hepatobiliary and Pancreatic Medical Treatment Center, People's Hospital of Xinjiang Uygur, Autonomous Region, Tianchi road, Urumqi, 830011, China.
With the advancement of precise hepatobiliary surgery concepts, the diagnostic and therapeutic approaches for hepatic echinococcosis have undergone significant transformations. However, whether these changes have correspondingly improved patient outcomes remains unclear. A retrospective analysis of these changes will provide crucial guidance for the prevention and treatment of hepatic echinococcosis.
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