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The Multifaceted Impact of Gallstones: Understanding Complications and Management Strategies.
Cureus
June 2024
Anesthesia and Critical Care, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, IND.
Gallstones, or cholelithiasis, represent a prevalent gastrointestinal disorder characterized by the formation of calculi within the gallbladder. This review aims to provide a comprehensive analysis of the complications associated with gallstones, with a focus on their pathophysiology, clinical manifestations, diagnostic methodologies, and management strategies. Gallstone-related complications encompass a broad spectrum, including biliary colic, acute cholecystitis, choledocholithiasis, acute pancreatitis, and cholangitis.
View Article and Find Full Text PDFPercutaneous thrombolysis via cholecystostomy catheter to dissolve biliary clots causing obstructive jaundice.
J Surg Case Rep
February 2024
Department of General Surgery, The Prince Charles Hospital, 627 Rode Rd, Chermside QLD0, Queensland 4032, Australia.
Haemobilia, or bleeding within the biliary tree, is rare. It can cause biliary obstruction secondary to blood clots. A comorbid 87-year-old was admitted to hospital with acute cholecystitis, choledocholithiasis, and an bacteremia.
View Article and Find Full Text PDFModified dietary fat intake for treatment of gallstone disease in people of any age.
Cochrane Database Syst Rev
February 2024
Centre for Research in Primary and Community Care, University of Hertfordshire, Hatfield, UK.
Article Synopsis
- - The prevalence of gallstones can range from less than 1% to 64% across different populations, with a growing concern attributed to dietary changes and rising obesity rates. Symptoms appear in 2% to 4% of those affected annually, primarily manifesting as severe abdominal pain, with surgery (cholecystectomy) being the main treatment for symptomatic cases.
- - The study aimed to assess the effectiveness and risks associated with adjusting dietary fat intake for treating gallstone disease, applicable to all age groups.
- - A thorough search of various medical databases and trial registries was conducted to find randomized clinical trials focusing on gallstones, ensuring inclusion of proper diagnosis and exclusion of confounding conditions.
[Approach to the Diagnosis and Management of Gallstones].
Korean J Gastroenterol
May 2023
Division of Gastroenterology, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea.
Gallstones are relatively common in the general population, and the clinical presentation is asymptomatic in most patients or has a benign course, such as biliary colic or vague gastrointestinal symptoms. On the other hand, it sometimes causes life-threatening complications, such as cholecystitis and pancreatitis. Asymptomatic gallstones do not require specific treatment, but a cholecystectomy may be necessary if the patient has a high risk of complications or gallbladder cancer.
View Article and Find Full Text PDFPrediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with Laboratory Methods.
Altern Lab Anim
January 2023
Prosilico AB, Huddinge, Sweden.
There is an ongoing aim to replace animal and laboratory models with methods. Such replacement requires the successful validation and comparably good performance of the alternative methods. We have developed an prediction system for human clinical pharmacokinetics, based on machine learning, conformal prediction and a new physiologically-based pharmacokinetic model, i.
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