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Single-Cell Lineage Tracing and Clonal State-Fate Analysis.
Methods Mol Biol
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.
Lineage tracing has significantly advanced our comprehension in many areas of biology, such as development or immunity, by precisely measuring cellular processes like migration, division, or differentiation across labeled cells and their progeny. Traditional recombinase-based prospective lineage tracing is limited by the need for a priori cell type information and is constrained in the numbers of clones it can simultaneously track. In this sense, clonal lineage tracing with integrated random barcodes offers a robust alternative, enabling researchers to label and track a vast array of cells and their progeny over time.
View Article and Find Full Text PDFA Distinguished Roadmap of Fibroblast Senescence in Predicting Immunotherapy Response and Prognosis Across Human Cancers.
Adv Sci (Weinh)
December 2024
Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Article Synopsis
- Tumor resistance to immune checkpoint inhibitors may be connected to cellular senescence, particularly in fibroblasts, as shown by single-cell RNA sequencing analyses.
- A fibroblast senescence-associated transcriptomic signature (FSS) links cellular senescence to tumor progression and immune dysfunction, demonstrating high predictive accuracy for ICI responses using machine learning.
- CDC6 is identified as a key marker influencing ICI response by inducing fibroblast senescence and altering the tumor microenvironment, highlighting the potential for targeting fibroblast senescence in cancer therapy.
Spatiotemporal single-cell roadmap of human skin wound healing.
Cell Stem Cell
December 2024
Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 17176 Stockholm, Sweden. Electronic address:
Wound healing is vital for human health, yet the details of cellular dynamics and coordination in human wound repair remain largely unexplored. To address this, we conducted single-cell multi-omics analyses on human skin wound tissues through inflammation, proliferation, and remodeling phases of wound repair from the same individuals, monitoring the cellular and molecular dynamics of human skin wound healing at an unprecedented spatiotemporal resolution. This singular roadmap reveals the cellular architecture of the wound margin and identifies FOSL1 as a critical driver of re-epithelialization.
View Article and Find Full Text PDFTargeting T cell exhaustion: emerging strategies in non-small cell lung cancer.
Front Immunol
December 2024
Department of Thoracic Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China.
Lung cancer continues to be a major contributor to cancer-related deaths globally. Recent advances in immunotherapy have introduced promising treatments targeting T cell functionality. Central to the efficacy of these therapies is the role of T cells, which are often rendered dysfunctional due to continuous antigenic stimulation in the tumor microenvironment-a condition referred to as T cell exhaustion.
View Article and Find Full Text PDF"Are we ready to transition from the Global Alliance for Vaccines and Immunization support?" Perceptions from 15 Kenyan counties.
Pan Afr Med J
December 2024
Division of Population Health, Sheffield Centre for Health and Related Research, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.
Introduction: Gavi, the Vaccine Alliance, defined a transition roadmap for countries receiving funding support based on their income status projections. According to the latest projections, Kenya will complete their transition from vaccine funding in 2029. While eligible countries are kept informed and supported for a smooth transition process, the extent to which countries understand the significant implications of a complete end of GAVI support on immunization service delivery varies.
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