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| http://dx.doi.org/10.1104/pp.20.01271 | DOI Listing |
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Nanyang Technological University, School of Chemistry, Chemical Engineering and Biotechnology, SINGAPORE.
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View Article and Find Full Text PDFSelective Inhibitory Effect of Hesperetin on the Automaticity of the Guinea Pig Pulmonary Vein Myocardium.
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The effect of a citrus-derived flavonoid, hesperetin, on the automaticity and contraction of isolated guinea pig myocardium was examined. Hesperetin inhibited the rate of ectopic action potential firing of the pulmonary vein myocardium; the slope of the diastolic depolarization was decreased with minimum change in the action potential waveform. The effect was dependent on the concentration; the EC value for firing rate was 56.
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