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Immunity to Non-Dengue Flaviviruses Impacts Dengue Virus Immunoglobulin G Enzyme-Linked Immunosorbent Assay Specificity in Cambodia.
J Infect Dis
September 2024
Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Article Synopsis
- Seroprevalence studies are essential for monitoring diseases, but the presence of multiple flaviviruses and vaccination efforts complicate testing for dengue virus, a key focus of this research.
- A study involving 770 children in Cambodia assessed the performance of a common dengue serology test, revealing lower specificity than expected and highlighting that many false positives had immunity to other flaviviruses.
- The findings suggest increasing the cut point for the dengue IgG test can improve accuracy, and there is a need for public health awareness regarding the presence of West Nile virus in the region.
Evaluation of COVID-19 rapid antigen test against polymerase chain reaction test in immunocompromised patients.
PLoS One
August 2024
Molecular Laboratory, Augusta Victoria Hospital, East Jerusalem, Palestine.
Article Synopsis
- The COVID-19 pandemic, which began in March 2020, led to the development of various testing methods and antiviral medications to combat the disease and its severe impacts on global health.
- A study conducted on 556 oncology patients at Augusta Victoria Hospital aimed to assess the sensitivity and specificity of the Panbio rapid antigen test, finding a sensitivity of 69.9% and a perfect specificity of 100%.
- Results showed that lower cycle threshold (Ct) values were linked to higher detection rates of the virus, with significant statistical evidence indicating that the PCR test is more sensitive than the rapid antigen test.
Performance evaluation of SARS-CoV-2 rapid diagnostic tests in Nigeria: A cross-sectional study.
PLOS Glob Public Health
July 2024
Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
The COVID-19 pandemic challenged health systems globally. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for detecting the presence of SARS-CoV-2 in clinical samples. Rapid diagnostic test (RDT) kits for COVID-19 have been widely used in Nigeria.
View Article and Find Full Text PDFClinical Evaluation of the Accuracy of the Panbio™ COVID-19/Flu A&B Rapid Panel: A Combination Antigen Rapid Diagnostic Test for the Omicron Variant and Influenza A Virus.
Viral Immunol
August 2024
Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan.
Article Synopsis
- The study evaluated a new antigen rapid diagnostic test (Ag-RDT) called Panbio™ COVID-19/Flu A&B, which can detect both SARS-CoV-2 and influenza A/B simultaneously.
- The test was validated using samples from 235 patients showing respiratory symptoms, with results showing high accuracy against the Omicron variant (sensitivity of 94.8% and specificity of 100%).
- Additionally, the test demonstrated strong performance for identifying influenza A, with positive and negative predictive values of 98.5% and 98.1%, indicating its effectiveness in clinical settings.
Diagnostic accuracy of Dengue NS1 lateral flow immunoassay in comparison to reverse transcriptase polymerase chain reaction and enzyme linked Immunosorbent Assay.
J Virol Methods
September 2024
Agappe Diagnostics Limited, Research & Development Department, Agappe Hills, Pattimattom P O, Ernakulam, Kerala, India.
The most widely used invitro diagnostic qualitative screening method for dengue virus infection is the lateral flow immunoassay technique. Testing of dengue non-structural antigen NS1 offers specificity in determining the active infection while testing of IgM and IgG helps in differentiating the primary and secondary dengue infections. The ELISA functions as the golden standard for dengue testing and PCR credits for the most accurate determination tool at the genetic level.
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