Although heat exposure is the leading cause of mortality for undocumented immigrants attempting to traverse the Mexico-U.S. border, there has been little work in quantifying risk. Therefore, our study aims to develop a methodology projecting increase in core temperature over time and space for migrants in Southern Arizona using spatial analysis and remote sensing in combination with the heat balance equation-adapting physiological formulae to a multi-step geospatial model using local climate conditions, terrain, and body specifics. We sought to quantitatively compare the results by demographic categories of age and sex and qualitatively compare them to known terrestrial conditions and prior studies of those conditions. We demonstrated a more detailed measure of risk for migrants than those used most recently: energy expenditure and terrain ruggedness. Our study not only gives a better understanding of the 'funnel effect' mechanisms, but also provides an opportunity for relief and rescue operations.
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http://dx.doi.org/10.1016/j.sste.2020.100363 | DOI Listing |
Sci Rep
December 2024
Puyang Key Laboratory of Sound Field Assisted Oil and Gas Development, Puyang, 457000, China.
Irreducible water saturation is an important factor affecting the development effect of low permeability reservoir. Using the self-developed ultrasonic generator, kerosene was used as simulated oil, the natural low-permeability siltstone cores with different physical properties in Zhongyuan Oilfield were selected for indoor oil displacement experiment, and the effect of ultrasonic action on the saturation of irreducible water in low-permeability reservoirs was evaluated. It was found that ultrasound can further reduce the saturation of irreducible water on the basis of oil flooding.
View Article and Find Full Text PDFUntil the beginning of the century, bleeding management was similar in elective surgeries or exsanguination scenarios: clotting tests were used to guide blood product orders and, while awaiting these results, an aggressive resuscitation with crystalloids was recommended. The high mortality rate in severe hemorrhages managed with this strategy endorsed the need for a special resuscitation plan. As a result, modifications were recommended to develop a new clinical approach to these patients, called "Damage Control Resuscitation".
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
College of Biosystems Engineering & Food Science, Zhejiang University, Hangzhou 310058, China. Electronic address:
pH changes occur during bodily lesions, presenting an opportunity for leveraging pH-responsive delivery systems as signals for a targeted response. This review explores the design and application of pH-responsive delivery systems based on natural polysaccharides for the controlled release of bioactives. The article examines the development of diverse delivery carriers, including nanoparticles, nanofibers, nanogels, core-shell carriers, hydrogels, emulsions as well as liposomes and their capacity to respond to pH variations, enabling the precise and targeted delivery of bioactives within the human body.
View Article and Find Full Text PDFEur J Pharm Sci
December 2024
Institute of Pharmaceutical Sciences, University of Freiburg, 79104 Freiburg im Breisgau, Germany; Andreas Hettich GmbH & Co. KG, 78532 Tuttlingen, Germany.
Thermosensitive liposomes (TSLs) have great potential for the selective delivery of cytostatic drugs to the tumor site with greatly reduced side effects. Here we report the discovery and characterization of new thermosensitive small multilamellar lipid nanoparticles (tSMLPs) with unusually high temperature selectivity. Furthermore, the temperature-dependent release of the fluorescent marker calcein from tSMLPs is enhanced by human serum albumin.
View Article and Find Full Text PDFNanomaterials (Basel)
December 2024
Material Science, BASF SE, RGA/BM-B007, Carl-Bosch-Str. 38, D-67056 Ludwigshafen, Germany.
The controlled formation and stabilization of nanoparticles is of fundamental relevance for materials science and key to many modern technologies. Common synthetic strategies to arrest growth at small sizes and prevent undesired particle agglomeration often rely on the use of organic additives and require non-aqueous media and/or high temperatures, all of which appear critical with respect to production costs, safety, and sustainability. In the present work, we demonstrate a simple one-pot process in water under ambient conditions that can produce particles of various transition metal carbonates and sulfides with sizes of only a few nanometers embedded in a silica shell, similar to particles derived from more elaborate synthesis routes, like the sol-gel process.
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