Gaussian process tomography (GPT) is a method used for obtaining real-time tomographic reconstructions of the plasma emissivity profile in tokamaks, given some model for the underlying physical processes involved. GPT can also be used, thanks to Bayesian formalism, to perform model selection, i.e., comparing different models and choosing the one with maximum evidence. However, the computations involved in this particular step may become slow for data with high dimensionality, especially when comparing the evidence for many different models. Using measurements collected by the Soft X-Ray (SXR) diagnostic in the ASDEX Upgrade tokamak, we train a convolutional neural network to map SXR tomographic projections to the corresponding GPT model whose evidence is highest. We then compare the network's results, and the time required to calculate them, with those obtained through analytical Bayesian formalism. In addition, we use the network's classifications to produce tomographic reconstructions of the plasma emissivity profile.
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PLoS One
January 2025
Institute for Physical Activity and Nutrition, Deakin University, Melbourne, VIC, Australia.
Heart disease remains a leading cause of mortality and morbidity worldwide, necessitating the development of accurate and reliable predictive models to facilitate early detection and intervention. While state of the art work has focused on various machine learning approaches for predicting heart disease, but they could not able to achieve remarkable accuracy. In response to this need, we applied nine machine learning algorithms XGBoost, logistic regression, decision tree, random forest, k-nearest neighbors (KNN), support vector machine (SVM), gaussian naïve bayes (NB gaussian), adaptive boosting, and linear regression to predict heart disease based on a range of physiological indicators.
View Article and Find Full Text PDFJ Math Biol
January 2025
Laboratory of Mathematics and Complex Systems, Ministry of Education, School of Mathematical Sciences, Beijing Normal University, Beijing, People's Republic of China.
Networked evolutionary game theory is a well-established framework for modeling the evolution of social behavior in structured populations. Most of the existing studies in this field have focused on 2-strategy games on heterogeneous networks or n-strategy games on regular networks. In this paper, we consider n-strategy games on arbitrary networks under the pairwise comparison updating rule.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Background: The spread of tau in Alzheimer's Disease (AD) can be tracked in vivo using [F-18]MK6240, a PET radioligand that binds to tau aggregates in AD with high affinity. However, significant MK6240 signal is also observed in the meninges and sinus and the extra cerebral binding (ECB) signal from these regions can spill into exterior brain regions complicating evaluation of early stage AD tauopathy. This study evaluates the magnitude and variability of ECB in a large imaging cohort to identify trends in this signal.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Background: Differences in task-fMRI activation have recently been found to be related to neuropathological hallmarks of AD. However, the evolution of fMRI-based activation throughout AD disease progression and its relationship with other biomarkers remains elusive. Applying a disease progression model (DPM) to a multicentric cohort with up to four annual task-fMRI visits, we hope to provide a deeper insight into these relationships.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
Background: Connectome-based models of disease propagation are used to probe mechanisms of pathology spread in neurodegenerative disease. We present our network spreading model toolbox that allows the user to compare model fits across different models and parameters. We apply the toolbox to assess whether local amyloid levels affect production of pathological tau.
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