AI Article Synopsis
- Four new diterpenoids, named rubellawus A-D, were discovered in the flowers of the plant Callicarpa rubella, along with three previously known compounds.
- The chemical structures of these compounds were determined using different spectroscopic techniques.
- The compounds were tested for anti-inflammatory properties, and two specific acids showed notable inhibitory effects on the NLRP3 inflammasome, making them potential candidates for further research.
Article Abstract
Four new diterpenoids, rubellawus A-D (1-4), along with three known compounds, were isolated and identified from the flowers of Callicarpa rubella. Their structures were elucidated by various spectroscopic analysis. All the compounds were screened for their anti-inflammatory activity and 14α-hydroxyisopimaric acid and isopimaric acid showed significant NLRP3 inflammasome inhibitory activity with IC values of 7.02 and 3.99 μM.
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| http://dx.doi.org/10.1002/cbdv.202000798 | DOI Listing |
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