AI Article Synopsis
- The immune response against SARS-CoV-2 in human milk has not been studied, but it is essential for protecting infants and young children from COVID-19 and limiting its spread.
- A study tested milk samples from COVID-19-recovered and suspected donors, finding that all samples had significant immune responses, especially with the IgA antibody targeting the virus's Spike protein.
- The research showed a strong correlation between IgA and secretory antibodies, suggesting a dominant IgA response in human milk, highlighting the need for further studies on antibody functionality and potential therapeutic uses.
Article Abstract
The SARS-CoV-2 immune response in human milk has not yet been examined, although protecting infants and young children from COVID-19 is critical for limiting community transmission and preventing serious illness and death. Here, milk samples from eight COVID-19-recovered and seven COVID-19-suspected donors were tested for antibody (Ab) binding to the SARS-CoV-2 Spike protein. All samples exhibited significant specific IgA reactivity to the full Spike, whereas 80% exhibited significant IgA and secretory (s)Ab binding to the Receptor-Binding Domain (RBD). Additionally, 67% samples exhibited IgG and/or IgM binding to RBD. IgA and sAb titers were highly correlated, indicating most IgA to be sIgA. Overall, these data indicate that a robust sIgA-dominant SARS-CoV-2 Ab response in human milk after infection should be expected in a significant majority of individuals. Further research is highly warranted to determine Ab functionality and the potential for exploiting extracted milk sIgA for therapeutic use.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586930 | PMC |
| http://dx.doi.org/10.1016/j.isci.2020.101735 | DOI Listing |
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