New quinoline-based thiazole derivatives and were synthesized and characterized by various spectroscopic and single-crystal X-ray crystallographic studies. The metal-sensing properties of the probes were further examined by absorption and fluorescence spectrometry. The fluorescence intensity of and was remarkably quenched during the addition of Fe, Fe, and Cu ions in THF/HO (1:1) at pH = 7.4 in HEPES buffer, while the addition of other metal ions did not affect the fluorescence intensity of the ligands. The detection ability of the probes and was further investigated by titration with various equivalents of metal ions, optimized pH ranges for detection, and reversibility with NaEDTA for biological applications.
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