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| http://dx.doi.org/10.1097/GOX.0000000000002936 | DOI Listing |
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Social network intervention for loneliness and social isolation in a community setting: the PALS cluster-RCT.
Public Health Res (Southampt)
March 2025
The Centre for Ageing and Dementia Research (CADR), School of Health and Social Care, Swansea University, Swansea, Wales, UK.
Background: Loneliness and social isolation are associated with adverse mental and physical health outcomes in adults. However, there is a lack of existing research on effective interventions and the contexts in which these could be implemented.
Primary Objective: To assess the clinical and cost-effectiveness of a social network intervention compared to usual care among at-risk populations.
A Sandwich-Type Double-Layer Amniotic Membrane Graft for Repairing Myopic Macular Hole-Related Retinal Detachment in a Child with Knobloch Syndrome.
Turk J Ophthalmol
February 2025
Gazi University Faculty of Medicine, Department of Ophthalmology, Ankara, Türkiye.
This case report describes a surgical technique using double-layer human amniotic membrane (hAM) grafting to repair a high myopic macular hole (MH)-related chronic retinal detachment (RD) with subretinal bands in a child with Knobloch syndrome. A 4-year-old boy diagnosed with Knobloch syndrome presented with macular atrophy in the right eye and chronic total RD with subretinal bands associated with a myopic MH in the left eye. The surgery involved an encircling band, pars plana vitrectomy, and subretinal band extraction through a retinotomy.
View Article and Find Full Text PDFAnalysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inflammatory reactions.
Front Immunol
February 2025
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Introduction: Critically ill patients suffer from a wide variety of clinical events, most of them leading to pro-inflammatory states such as sepsis or simply as consequence of major surgery. Many of these patients develop forms of acute kidney injury, heart or acute liver failure during intensive care. Lipid signaling is critically involved in triggering systemic inflammation processes, pain and vascular tone.
View Article and Find Full Text PDFAstrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain.
Cell Rep
February 2025
Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address:
Intense brain activity elevates extracellular potassium, potentially leading to overexcitation and seizures. Astrocytes are crucial for restoring healthy potassium levels, and an emerging focus on their Kir4.1 channels has reopened the quest into the underlying mechanisms.
View Article and Find Full Text PDFA new future for dog breeding.
Anim Welf
January 2025
Department of Veterinary and Animal Sciences, University of Copenhagen, Grønnegårdsvej 8, DK-1870, Frederiksberg C, Denmark.
The modern idea of purebred dogs has come under increasing critical scrutiny over recent decades. In light of this critical focus and other developments in society, some new trends in how companion dogs are bred and acquired have emerged. This means a diminishing influence from traditional kennel clubs with more dogs being sold without a pedigree, stricter legal restrictions on dog breeding, growing popularity of deliberate crosses of established breeds (i.
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