There is increasing evidence from animal and human studies that glaucoma is an autoimmune disease. Evidence for this hypothesis includes the fact that antibodies as well as T-cell responses to heat-shock proteins (HSPs) are detectable in some patients with glaucoma and in an animal model of the disease. As in the human disease, experimental animal models of glaucoma have been found to demonstrate neurodegenerative changes in the optic nerve associated with immunoglobulin and T-cell infiltration. Although there is still insufficient evidence in humans to classify all cases of glaucoma as autoimmune diseases, the implications of this hypothesis have major impact on the diagnosis and treatment of glaucoma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586712 | PMC |
| http://dx.doi.org/10.1002/cti2.1180 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Potential Causal Association Between Atrial Fibrillation/Flutter and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomisation Study.
J Clin Med
December 2024
Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea.
: A few studies have reported controversial relationships between atrial fibrillation/flutter (AF/L) and primary open-angle glaucoma (POAG). This study aimed to investigate the potential causal relationship between AF/L and POAG. : Single-nucleotide polymorphisms associated with exposure to AF/L were selected as instrumental variables with significance ( < 5.
View Article and Find Full Text PDFClinical Outcomes and Early Postoperative Complications in Boston Type I Keratoprosthesis Implantation: A Retrospective Study.
J Clin Med
November 2024
Department of Ophthalmology, District Railway Hospital, 40-760 Katowice, Poland.
The purpose of this study is to evaluate clinical outcomes and early postoperative complications in patients undergoing Boston type I keratoprosthesis (BKPro) implantation, with a specific focus on the onset and nature of ocular surface disorders during the early postoperative period. This retrospective study included 77 eyes that underwent BKPro implantation between 2019 and March 2022. Patients were treated at the Saint Barbara Hospital, Trauma Centre, Sosnowiec, Poland, and District Railway Hospital, Katowice, Poland.
View Article and Find Full Text PDFThe Role of Gut Microbiota in the Pathogenesis of Glaucoma: Evidence from Bibliometric Analysis and Comprehensive Review.
Bioengineering (Basel)
October 2024
Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410017, China.
The relationship between gut microbiota and glaucoma has garnered significant interest, with emerging evidence suggesting that gut dysbiosis, inflammation, and immune mechanisms may contribute to glaucoma pathogenesis. Understanding these interactions through the gut-retina axis offers new insights into disease progression and potential therapeutic options. This study combines bibliometric analysis and literature review to evaluate research trends and key research areas related to gut microbiota's role in glaucoma.
View Article and Find Full Text PDFDry Eye Disease Prevalence and Associated Risk Factors Among the Middle East Population: A Systematic Review and Meta-Analysis.
Cureus
September 2024
Department of Optometry, College of Applied Medical Sciences, University of Jeddah, Jeddah, SAU.
Article Synopsis
- Dry eye disease (DED) is a widespread issue resulting in discomfort and damage to the eyes, with varying prevalence based on regional factors like environment and genetics.
- This study systematically reviewed existing research to determine the prevalence and risk factors of DED specifically in the Middle East, analyzing data from 17 studies involving over 22,000 individuals.
- The findings showed a DED prevalence of 28.33% in the region, with key risk factors including age, female gender, smoking, and lifestyle habits like prolonged screen time, suggesting the need for tailored prevention and management strategies.
Association between central corneal thickness and systemic lupus erythematosus: a cross-sectional study protocol.
Front Med (Lausanne)
October 2024
Department of Clinical Medicine, School of Medicine, Miguel Hernández de Elche University, San Juan de Alicante, Spain.
Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple systems and classified under connective tissue disorders. Ocular involvement occurs in up to 30% of SLE cases, with the cornea being particularly susceptible to thinning due to immune-complex deposits and its predominantly type I collagen composition. This corneal thinning is clinically significant in glaucoma, where patients with reduced central corneal thickness (CCT) may have up to a threefold increased risk of developing glaucoma, as well as in refractive surgery.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!