Background: With the development of 4th generation ceramic bearing, the large ceramic head is available for ceramic-on-ceramic total hip arthroplasty (THA). This retrospective study aimed to compare the outcomes of ceramic-on-ceramic THA with 4th generation 36 mm head to those with 3rd generation 28 mm head using propensity score matching.
Methods: We retrospectively reviewed the results of 133 ceramic-on-ceramic THAs with 4th generation 36 mm ceramic head in 129 patients and 133 ceramic-on-ceramic THAs identified from 405 ceramic-on-ceramic THAs with 3rd generation 28 mm head by propensity score matching. There were 83 males and 50 females in both groups with a mean age of 55 years. There was no significant difference in other demographic features except for follow-up period (4.2 years in the 36 mm group and 6.4 years in the 28 mm group, < 0.001). Clinical and radiological results and occurrence of complication were compared between the two groups.
Results: Harris Hip Score was increased significantly from 46.4 to 92.1 in the 36 mm group and from 46.7 to 93.6 in the 28 mm group. No loosening or osteolysis was observed in the 36 mm group. However, one hip showed radiologic sign of loosening in the 28 mm group. As for complication, postoperative dislocation was more frequent in the 28 mm group (6 in the 28 mm group vs. 0 in the 36 mm group, = 0.03). Otherwise, there was no significant difference in other results including inguinal pain, squeaking or ceramic fracture.
Conclusion: Ceramic-on-ceramic THA with 4th generation 36 mm head significantly reduced postoperative dislocation rate without increasing the rate of inguinal pain, squeaking, or ceramic fracture compared to that with 3rd generation 28 mm head.
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http://dx.doi.org/10.1007/s43465-020-00242-z | DOI Listing |
Alzheimers Dement
December 2024
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Background: Alzheimer's disease (AD)-related biomarkers assessed in blood have proved to be useful for detecting dementia and cognitive impairment in the memory clinic. However, less is known about their predictive value in the long-term and in a community-based setting.
Method: We examined six common serum-derived biomarkers of AD (P-tau181, T-tau, Aβ42/Aβ40 ratio, P-tau181/Aβ42 ratio, Nfl, and GFAP) from the baseline assessment of the population-based Swedish National Study on Aging and Care in Kungsholmen (SNAC-K; n = 2071, mean age at baseline = 72 years).
Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Stressors occurring over the lifespan (i.e., lifetime stressor exposure) are hypothesized to contribute to greater risk of cognitive decline and dementia.
View Article and Find Full Text PDFBiomed Mater
January 2025
Lab of Stem Cells and Tissue Engineering, State Key Lab of Biotherapy, Sichuan University West China Hospital, No.1, Keyuan 4th Rd, High-Tech District, Chengdu, 610041, CHINA.
The selection of appropriate cell sources is vital for the regeneration and repair of tendons using stem cell-based approaches. Human adipose-derived stem cells (hADSCs) have emerged as a promising therapeutic strategy for tendon injuries. However, the heterogeneity of hADSCs can lead to inconsistent or suboptimal therapeutic outcomes.
View Article and Find Full Text PDFEpilepsy Behav
December 2024
Selcuk University Medical Faculty, Fifth Year Medical Student, Konya, Turkey.
Objective: The aim of this study is to evaluate the epilepsy-related knowledge and attitudes toward epilepsy in medical students. In addition, these parameters were evaluated according to national geographic regions, preclinical and clinical characteristics.
Methods: This study was a cross-sectional, observational design and it was conducted among medical students in a centrally located city, Turkey.
J Agric Food Chem
December 2024
Institute of Medical Biochemistry and Laboratory Diagnostics, and 4th Department of Internal Medicine, General University Hospital in Prague and 1st Faculty of Medicine, Charles University, Na Bojišti 3, Prague 2 12108, Czech Republic.
Flavonoids are naturally occurring compounds found in fruits, vegetables, and other plant-based foods, and they are known for their health benefits, such as UV protection, antioxidant, anti-inflammatory, and antiproliferative properties. This study investigates whether flavonoids, such as quercetin and 2,3-dehydrosilybin, can act as photoactivatable carbon monoxide (CO)-releasing molecules under physiological conditions. CO has been recently recognized as an important signaling molecule.
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