Fibroblastic reticular cells (FRCs) are the specialized lymphoid stromal cells initially identified as triggering T-cell recruitment and dynamic motion in secondary lymphoid organs. Interestingly, FRCs also display antigen presentation capacities and support lymphocyte survival. CXCR5CD4 follicular T cells are important players of B-cell maturation and antibody response. Our study reported that -differentiated FRC-like cells enhanced the growth of the whole CXCR5CD4 T-cell compartment, while enhancing IL-4 secretion specifically by the PD1CXCR5CD4 cell subset, in a Notch- and ICAM1/LFA1-dependent manner. In addition, we revealed that in follicular lymphoma (FL) tissues, previously identified as enriched for PD1CXCR5CD4 mature follicular helper T cells, PD1CXCR5CD4 T cells displayed an enrichment for Notch and integrin gene signatures, and a Notch and ICAM-1-dependent overexpression of IL-4 compared to their non-malignant counterparts. These findings suggest that the crosstalk between FRCs and CXCR5PD1CD4 T cells may contribute to the FL IL-4 rich environment, thus providing new insights in FL lymphomagenesis.
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| http://dx.doi.org/10.3389/fimmu.2020.559866 | DOI Listing |
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