Evaluation of the chemical constituents and potential biological activities of .

The aim of this work is to evaluate the chemical constituents and potential biological activists of Three fatty acids were isolated using column chromatography and identified as palmitic acid (F1), oleic acid (F2) and stearic acid (F3) in addition to other two steroidal compounds; α-amyrin (A4), and β-sitosterol (A5). Using GC, ten fatty acids were detected the major fatty acid obtained was stearic acid (74.61%) while palmitic acid was the second high percentage (10.35%), and the least percentage obtained was arachidic acid (0.07%). extract showed antimicrobial activities against some microorganisms. The highest activity of total extract was reported against (18.3 ± 0.03 mm.) followed by (15.3 ± 0.05), while the lowest were for both & (6.7 ± 0.06 and 5.9.0 ± 0.9 mm. respectively). The three isolated compounds (F1-3) showed activities against aureus, and only. The highest activity was aganist Staphylococcus aureus (13.0 ± 0.1 mm.). The highest effect was obtained by compound F3 (stearic acid) (15.0 ± 0.5 mm.), and compound F1 (oleic acid) (13.0 ± 0.1 mm.) and F2 (palmitic acid) 11.0 ± 0.3 mm. The total ethanol extract of the investigated fungus was safe up to 5000 mg kg and did not produce any significant change in liver and kidney functions after oral administration (400 mg kg) for 14 consecutive days. The results reported the isolation of some fungal new driving compounds which has been not isolated before from species in addition to their correlated new biological activities.