AI Article Synopsis
- A 40-year-old Japanese woman experienced severe hypertension leading to kidney failure and was later diagnosed with pulmonary hypertension and interstitial pneumonia.
- Despite not having visible skin issues, tests indicated she had anti-PM/Scl antibody-positive systemic sclerosis, often linked to various organ diseases.
- The ongoing presence of these antibodies suggests her kidney problems were related to a scleroderma renal crisis, highlighting the importance of thorough testing for autoimmune diseases.
Article Abstract
A 40-year-old Japanese woman developed malignant-phase hypertension complicated by thrombotic microangiopathy, progressing to end-stage renal disease. Five years later, she was diagnosed with pulmonary arterial hypertension and interstitial pneumonia. Despite a lack of overt skin sclerosis, nucleolar staining in our indirect immunofluorescence analysis and nailfold capillaroscopy facilitated the diagnosis of anti-PM/Scl antibody-positive systemic sclerosis. We observed the persistent presence of anti-PM/Scl antibodies throughout the clinical course, suggesting that her kidney disease was scleroderma renal crisis. Anti-PM/Scl antibodies can be associated with multiple organ diseases. Careful attention to a patient's antinuclear antibody pattern and dermatological findings may help clarify the etiology of undiagnosed diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8079901 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.5665-20 | DOI Listing |
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