AI Article Synopsis
- - A total of 26 new compounds based on the osthole skeleton were created and tested for their ability to protect cells from oxidative stress, inflammation, and neurotoxicity related to Alzheimer's disease, using various assays.
- - Among these, OST7 and OST17 showed significantly improved antioxidative and anti-inflammatory effects compared to the original osthole, with OST7 demonstrating strong neuroprotective activity at low concentrations.
- - Further analysis through molecular docking and structure-activity relationship studies suggested that certain chemical groups enhance the neuroprotective properties of these compounds, indicating their potential as new treatments for Alzheimer's disease.
Article Abstract
A total of 26 compounds based on osthole skeleton were designed, synthesized. Their cytoprotective abilities of antioxidation, anti-inflammation and Aβ(Amyloid β-protein 42)-induced neurotoxicity were evaluated by MTT assays. Mechanism of the action of selected compounds were investigated by molecular docking. AlogP, logS and blood-brain barrier (BBB) permeability of all these compounds were simulated by admetSAR. Most of the compounds showed better antioxidative and anti-inflammatory activities compared with osthole, especially OST7 and OST17. The compound OST7 showed relative high activity in neuroprotection against HO (45.7 ± 5.5%), oxygen glucose deprivation (64.6 ± 4.8%) and Aβ (61.4 ± 5.2%) at a low concentration of 10 μM. EC of selected compounds were measured in both HO and OGD induced cytotoxicity models. Moreover, NO inhibiting ability of OST17(50.4 ± 7.1%) already surpassed the positive drug indomethacin. The structure activity relationship study indicated that introduction of piperazine group, tetrahydropyrrole group and aromatic amine group might be beneficial for enhancement of osthole neuroprotective properties. Molecular docking explained that the reason OST7 exhibited relatively stronger neuroprotection against Aβ because of the greater area of interactions between molecule and target protein. OST7 and OST17 both provided novel methods to investigate osthole as anti-AD drugs.
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| http://dx.doi.org/10.1016/j.bmcl.2020.127633 | DOI Listing |
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