AI Article Synopsis
- Sunscreens can penetrate the skin, which may reduce their effectiveness and safety by entering systemic circulation and potentially causing unknown health issues.
- To ensure effectiveness, it's crucial for sunscreen filters to remain on the skin's surface with minimal penetration, while still protecting against skin damage and conditions like cancer caused by UV radiation.
- Ongoing studies focus on improving sunscreen formulas to reduce absorption into the skin and evaluate their sun protection factor (SPF), alongside reviewing recent data on sunscreen permeation and efficacy factors.
Article Abstract
Permeation of sunscreens agents reduces its effectiveness and safety, leading to systemic circulation and causing unknown adverse effects. In order to maintain the sunscreen efficacy and safety, the filters must stay on the skin surface, with minimum penetration through dermis. Even facing the possibility of filters permeation, the use of sunscreen is important to avoid skin damage as erythema, free-radicals formation, skin ageing and skin cancer, caused by ultraviolet radiation. Aiming potential side effects caused by topical absorption of sunscreens, studies are carried to improve formulation characteristics and stability, reduce skin permeation and evaluate sun protections factor (SPF). Current assays to detect the permeation of sunscreens involve in vivo or in vitro studies, to simulate physiological conditions of use. The aim of this review is to revisit sunscreen skin permeation data over the last decade and the factors that can enhance skin permeation or improve the sunscreen efficacy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2020.120013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!