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The use of a methylene blue and glyceryl trinitrate-based cream for the treatment of chronic anal fissures: a phase II randomized pilot trial from a referral coloproctological unit.
Tech Coloproctol
January 2025
Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J), Section of Surgery, General Surgery Unit - Hospital University of Bari, Piazza Giulio Cesare 11, 70124, Bari, SE, Italy.
Background: Chronic anal fissures (CAFs) are the second most common anorectal disease. Non-surgical treatment includes several options with controversial efficacy. The aim of this study was to evaluate the efficacy and safety of a new ointment based on methylene blue in addition to glyceryl trinitrate.
View Article and Find Full Text PDFOutcomes of Knee Dislocations and Subluxations in Polytrauma Patients at a Major Trauma Center.
Cureus
December 2024
Department of Trauma and Orthopaedics, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, GBR.
Background This is a retrospective service evaluation of outcomes of polytrauma patients sustaining knee dislocations and subluxations within a major trauma center (MTC). Polytrauma patients with knee dislocations are complex to manage and often sustain multiple life-threatening injuries. Although treatments have progressed, no consensus remains on management timing and strategy.
View Article and Find Full Text PDFManagement of Scapula Fractures at a Level 1 Trauma Centre in the United Kingdom.
Cureus
December 2024
Trauma and Orthopaedics, Barts Health NHS Trust, London, GBR.
Background Scapular fractures, an uncommon injury that can be brought on by a high-energy mechanism because of its proximity to the pectoral and shoulder muscles, are frequently linked to fatal injuries. This study aimed to compare surgical versus conservative treatment of scapular fractures and the results of treated patients. Methods The traumatic scapular fracture patients in this cross-sectional study (n = 391) were treated at a major trauma centre (level 1) in the United Kingdom between 2012 and 2018.
View Article and Find Full Text PDFA retrospective analysis of quality of life domains impacted by distal radius fracture and ulnar neuropathy.
J Hand Ther
December 2024
Faculty of Health Sciences, Western University, London, Ontario, Canada; Roth McFarlane Hand and Upper Limb Centre, St. Joseph's Hospital, London, Ontario, Canada; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.
Background: Distal radius fractures (DRF) and ulnar neuropathy (UNE) present with reduced motor function, restricted range of motion, pain, and reduced grip strength that may lead to similar treatment approaches. With rapid and insidious onset for DRF and UNE, respectively, the contextual factors impacting an individuals' experience with the condition can vary.
Purpose: The aim of this secondary analysis is to compare ratings of quality of life (QoL) domains prior to treatment and 3 months post treatment for DRF and UNE.
A Biokinetic Approach in Primary Knee Osteoarthritis Prevention and Management - Exploring Movement Profiles and Kinetic Chain Interactions: Current Concepts.
J ISAKOS
December 2024
Instituto Brasil de Tecnologias da Saúde (IBTS), Department of Research in Biomechanics, Rio de Janeiro, RJ, Brazil; Universidade Federal de São Paulo, Department of Diagnostic Imaging, São Paulo, SP, Brazil. Electronic address:
Knee osteoarthritis (OA) is a chronic disease characterized by increasing prevalence and significant physical, psychological, and economic burdens. Despite extensive research, the definition, risk factors, and effective cost-efficient treatments for knee OA remain unclear. This article aims to revisit primary knee OA, understanding its etiology, and focusing on prevention and individualized non-operative treatment modalities.
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