AI Article Synopsis
- Residual depressive symptoms can lead to long-term health issues for patients who have recovered from major depression (rMDD), but there are no clear neurobiological predictors for their recovery trajectory.
- rMDD patients underwent MRI scans to analyze brain structure and function, revealing that changes in the default mode network (DMN) are linked to shifts in depressive symptoms and the likelihood of relapse within two years.
- Findings indicate that greater connectivity in the DMN and larger volumes in specific brain regions are associated with better symptom outcomes, suggesting potential pathways for developing treatments aimed at preventing future depressive episodes in rMDD patients.
Article Abstract
Background: Serious long term health and economic detriment accompany residual depressive symptoms even in fully remitted depressed patients (rMDD). Neurobiological predictors for rMDD patients' illness trajectory are absent.
Methods: rMDD patients (n = 39, female = 26) underwent magnetic resonance imaging. Baseline analyses of brain structure via voxel-based morphometry and brain function via functional connectivity (FC) at rest were correlated with changes in the Hamilton Depression Rating Scale between baseline and follow-up, and incidence of a recurrent major depressive episode (MDE) within a 2-year period.
Results: Gray matter increases in default mode (DN) regions in the posterior cingulate cortex (PCC) and increased resting-state FC within the DN both predicted change of depressive symptoms. Patients with recurrent MDE had larger bilateral nucleus accumbens and left insula volumes. Post hoc exploratory analysis of nucleus accumbens and insula conceptualized as part of the brain's reward circuit demonstrated reduced connectivity in patients with recurrent MDE.
Conclusions: Higher DN connectivity and PCC volume coinciding with a more favorable course of symptoms suggest neural mechanisms of self-recovery beyond the phase of active medical treatment. Alterations in the brain's reward circuit might be a starting point for designing maintenance treatments that prevent recurrent MDEs in rMDD patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048641 | PMC |
| http://dx.doi.org/10.1002/da.23108 | DOI Listing |
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