Arteriovenous malformations are frequently found in the head and neck, and are occasionally associated with congenital syndromes. They are rarely reported in the foot and ankle; however, when encountered in these particular locations, they may become painful and interfere with ambulation. Because of the lack of literature on pedal arteriovenous malformations, they remain enigmatic when encountered clinically. They form as a result of atypical development of the vascular system during embryogenesis. The identification, diagnosis, and treatment of an arteriovenous malformation can be challenging, because it may present similarly to more frequent soft-tissue pathologies in podiatric practice. These include fibroma, lipoma, ganglion cyst, or proteinaceous cyst. They have unpredictable behavior and a high recurrence rate. Failure to recognize and treat an arteriovenous malformation appropriately could result in ulceration, hemorrhage, and amputation. The identification and diagnosis must be accompanied with a full vascular work-up to determine the magnitude, flow, and extent of the lesion. After vascular work up, conservative, and surgical treatment options can be explored. This is an unusual case report of an arteriovenous malformation of the plantar foot that was previously misdiagnosed, and later presented to our facility for a second opinion. The steps taken for identification, diagnosis, and treatment are discussed along with surgical technique for excision of an arteriovenous malformation with successful outcome at 1 year follow-up. This case report will provide clinicians with armamentarium for diagnosis, workup, and treatment, when considering arteriovenous malformation in the differential diagnosis.
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http://dx.doi.org/10.1053/j.jfas.2019.05.013 | DOI Listing |
BMJ Case Rep
January 2025
Neurosurgery, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Spinal dural arteriovenous fistulas (SDAVFs) are the most common type of spinal vascular malformations. Multiple SDAVFs are unusual and can occur either synchronously or metachronously, as reported in the literature. We report on the unusual case of a woman with three separate SDAVFs, which were surgically treated within the same setting; the postoperative course was characterised by unexplained repeated haematoma formation within the surgical sites.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK.
Introduction: Cerebrovascular dysfunction plays a critical role in the pathogenesis of dementia and related neurodegenerative disorders. Recent omics-driven research has revealed associations between vascular abnormalities and transcriptomic alterations in brain vascular cells, particularly endothelial cells (ECs) and pericytes (PCs). However, the impact of these molecular changes on dementia remains unclear.
View Article and Find Full Text PDFChin Neurosurg J
January 2025
Department of Neurosurgery, University Hospital Cruces, Bilbao, Basque Country, Spain.
Background: Delayed radiation-induced complications after stereotactic radiosurgery (SRS) for arteriovenous malformations (AVM) have scarcely been described in the literature, and their incidence, pathophysiology, and treatment remain unclear. Additionally, the literature regarding these complications is confusing. The authors present a well-documented case report describing these late complications, adding evidence to the possible common pathophysiological mechanism underlying them, and illustrating an effective treatment modality when they occur.
View Article and Find Full Text PDFBMC Gastroenterol
January 2025
Independent Researcher, İzmir, Turkey.
Background: Small-bowel angioectasia is commonly diagnosed and managed using double-balloon enteroscopy; however, rebleeding rates can vary significantly. This study aimed to identify and evaluate the clinical predictors of rebleeding in patients with small-bowel angioectasia.
Methods: This retrospective study focused on adult patients who underwent endoscopic management for small bowel vascular lesions (SBVLs).
The central nervous system (CNS) parenchyma has conventionally been believed to lack lymphatic vasculature, likely due to a non-permissive microenvironment that hinders the formation and growth of lymphatic endothelial cells (LECs). Recent findings of ectopic expression of LEC markers including Prospero Homeobox 1 (PROX1), a master regulator of lymphatic differentiation, and the vascular permeability marker Plasmalemma Vesicle Associated Protein (PLVAP), in certain glioblastoma and brain arteriovenous malformations (AVMs), has prompted investigation into their roles in cerebrovascular malformations, tumor environments, and blood-brain barrier (BBB) abnormalities. To explore the relationship between ectopic LEC properties and BBB disruption, we utilized endothelial cell-specific overexpression mutants.
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