Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human leukocyte, platelet-specific, or ABO antigens, but are a consequence of platelet sequestration and consumption. This review summarizes the clinical factors that result in platelet refractoriness and highlights recent data describing novel biological mechanisms that contribute to this clinical problem.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494440 | PMC |
| http://dx.doi.org/10.1016/j.tmrv.2020.09.002 | DOI Listing |
Publication Analysis
Top Keywords
refractoriness platelet
12
platelet transfusion
12
clinical problem
8
platelet
5
non-alloimmune mechanisms
4
mechanisms thrombocytopenia
4
refractoriness
4
thrombocytopenia refractoriness
4
transfusion
4
transfusion refractoriness
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!