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Bioavailability and spatial distribution of fatty acids in the rat retina after dietary omega-3 supplementation. | LitMetric

AI Article Synopsis

  • The study investigates how different forms of dietary n-3 fatty acids (FAs) affect the composition and organization of FAs in the retinas of Wistar rats.
  • Rats were fed diets containing either EPA or DHA in different lipid forms (phospholipids and triglycerides) for 8 weeks, and their retinal FA changes were analyzed.
  • Results showed that DHA content and spatial arrangement in the retina increased significantly with specific diets, indicating that omega-3 supplements can influence FA composition and organization in the retina, potentially aiding in age-related retinal protection.

Article Abstract

Spatial changes of FAs in the retina in response to different dietary n-3 formulations have never been explored, although a diet rich in EPA and DHA is recommended to protect the retina against the effects of aging. In this study, Wistar rats were fed for 8 weeks with balanced diet including either EPA-containing phospholipids (PLs), EPA-containing TGs, DHA-containing PLs, or DHA-containing TGs. Qualitative changes in FA composition of plasma, erythrocytes, and retina were evaluated by gas chromatography-flame ionization detector. Following the different dietary intakes, changes to the quantity and spatial organization of PC and PE species in retina were determined by LC coupled to MS/MS and MALDI coupled to MS imaging. The omega-3 content in the lipids of plasma and erythrocytes suggests that PLs as well as TGs are good omega-3 carriers for retina. However, a significant increase in DHA content in retina was observed, especially molecular species as di-DHA-containing PC and PE, as well as an increase in very long chain PUFAs (more than 28 carbons) following PL-EPA and TG-DHA diets only. All supplemented diets triggered spatial organization changes of DHA in the photoreceptor layer around the optic nerve. Taken together, these findings suggest that dietary omega-3 supplementation can modify the content of FAs in the rat retina.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707163PMC
http://dx.doi.org/10.1194/jlr.RA120001057DOI Listing

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