This study introduces a method that allows the generation and safety evaluation of a scenario catalog derived from potential car-pedestrian conflict situations. It is based on open-source software components and uses the road layout standard OpenDRIVE to derive participants' motion profiles with the support of available accident data. The method was implemented upon the open-source framework openPASS and can simulate results for different active safety system setups and facilitates the prediction of system capabilities to decrease the relative impact velocities and collision configurations such as the point of impact. A demonstration case was performed where the scenario catalog was derived and used to evaluate pedestrian collisions with and without a generic autonomous emergency braking (AEB) system. The AEB system aims to intervene in the event of an impending collision and might affect the outcome of a baseline scenario. The study indicated a change in the collision configuration and identified conflict situations less affected by the system. A particularly interesting finding was that some scenarios even led to a higher number of collisions (at lower impact) for the AEB intervention in comparison to the baseline cases.
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http://dx.doi.org/10.1016/j.aap.2020.105831 | DOI Listing |
mBio
January 2025
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Unlabelled: Bacterial typing at whole-genome scales is now feasible owing to decreasing costs in high-throughput sequencing and the recent advances in computation. The unprecedented resolution of whole-genome typing is achieved by genotyping the variable segments of bacterial genomes that can fluctuate significantly in gene content. However, due to the transient and hypervariable nature of many accessory elements, the value of the added resolution in outbreak investigations remains disputed.
View Article and Find Full Text PDFComput Biol Chem
January 2025
Bioinformatics Lab, Department of Statistics, Begum Rokeya University, Rangpur 5404, Bangladesh. Electronic address:
The advancements in single-cell RNA sequencing (scRNAseq) technology have significantly transformed genomics research, enabling the handling of thousands of cells in each experiment. As of now, 32,068 research studies have been cataloged in the Pubmed database. The primary aim of scRNAseq investigations is to identify cell types, understand the antitumor immune response, and identify new and uncommon cell types.
View Article and Find Full Text PDFPathogens
December 2024
Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
are indoor-dwelling vectors of many arboviruses, including Zika (ZIKV) and chikungunya (CHIKV). The dynamics of these viruses within the mosquito are known to be temperature-dependent, and models that address risk and predictions of the transmission efficiency and patterns typically use meteorological temperature data. These data do not differentiate the temperatures experienced by mosquitoes in different microclimates, such as indoor vs.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Department of Mathematics and Physics, University of Campania "Luigi Vanvitelli," Caserta, Italy.
The identification of patterns in space, time, and magnitude, which could potentially encode the subsequent earthquake magnitude, represents a significant challenge in earthquake forecasting. A pivotal aspect of this endeavor involves the search for correlations between earthquake magnitudes, a task greatly hindered by the incompleteness of instrumental catalogs. A novel strategy to address this challenge is provided by the groundbreaking observation by Van der Elst (Journal of Geophysical Research: Solid Earth, 2021) that positive magnitude differences, under specific conditions, remain unaffected by catalog incompleteness.
View Article and Find Full Text PDFOpen Mind (Camb)
September 2024
Department of Psychological & Brain Sciences, Johns Hopkins University, Baltimore, MD, USA.
Whereas decades of research have cataloged striking errors in physical reasoning, a resurgence of interest in intuitive physics has revealed humans' remarkable ability to successfully predict the unfolding of physical scenes. A leading interpretation intended to resolve these opposing results is that physical reasoning recruits a general-purpose mechanism that reliably models physical scenarios (explaining recent successes), but overly contrived tasks or impoverished and ecologically invalid stimuli can produce poor performance (accounting for earlier failures). But might there be tasks that persistently strain physical understanding, even in naturalistic contexts? Here, we explore this question by introducing a new intuitive physics task: evaluating the strength of knots and tangles.
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