AI Article Synopsis
- This study examines the link between obesity and the risk of developing acute kidney injury (AKI) after cardiac surgery by analyzing data from 1,601 patients and categorizing them based on body mass index (BMI).
- Findings indicated that both underweight and obese individuals faced an increased risk of AKI compared to those with a normal BMI, particularly when BMI exceeded 24.0.
- The results were confirmed through a meta-analysis, reinforcing the idea that abnormal BMI levels are independent risk factors for AKI following cardiac surgery.
Article Abstract
Objective: To determine the relationship between obesity and the risk of AKI after cardiac surgery (CS-AKI) in a cohort study.
Methods: A total of 1,601 patients undergoing cardiac surgery were collected and their incidence of CS-AKI was recorded. They were divided into underweight, normal weight, overweight, and obese groups. Logistic regression was used to estimate the association between BMI (body mass index) and CS-AKI risk. Then, a meta-analysis of published cohort studies was conducted to confirm this result using PubMed and Embase databases.
Results: A significant association was observed in this independent cohort after adjusting age, gender, hypertension and New York Heart Association classification (NYHA) class. Compared with normal BMI group (18.5 ≤ BMI < 24.0), the individuals with aberrant BMI level had an increased AKI risk (OR: 1.68, 95% CI: 1.01-2.78) for BMI < 18.5 group and (OR: 1.43, 95% CI: 0.96-2.15) for BMI ≥ 28.0. Interestingly, the U-shape curve showed the CS-AKI risk reduced with the increasing of BMI when BMI ≤ 24.0. As BMI increases with BMI > 24.0, the risk of developing CS-AKI increased significantly. In the confirmed meta-analysis, compared with normal weight, overweight group with cardiac surgery had higher AKI risk (OR: 1.28, 95% CI: 1.16-1.41, = 0.49). The similar association was found in obesity subgroup (OR: 1.79, 95% CI: 1.57-2.03, = 0.42).
Conclusion: In conclusion, the results suggested that abnormal BMI was a risk factor for CS-AKI independently.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573233 | PMC |
| http://dx.doi.org/10.3389/fendo.2020.534294 | DOI Listing |
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