As a major opportunistic pathogen, can produce various virulence factors and form biofilms. These processes are controlled by the quorum sensing (QS) system. Sodium new houttuyfonate (SNH) is an adduct of houttuyfonate, the main component of the common Chinese medicine plant Houttuynia cordata, which has antibacterial and anti-inflammatory effects. We evaluated the effect of SNH on biofilms, virulence factors, and transcription. Transcriptome analysis showed that the key and genes of the QS system were down-regulated after SNH treatment. SNH reduces proteases and pyocyanin production and inhibits biofilm formation by regulating the QS system. SNH also changes the expression of genes related to virulence factors and biofilms (, and ). These results suggested that the mechanism of SNH against by affecting the expression of biofilm and virulence factors controlled by quorum sensing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566558 | PMC |
| http://dx.doi.org/10.3389/fphar.2020.572375 | DOI Listing |
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