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PRC2-EZH1 contributes to circadian gene expression by orchestrating chromatin states and RNA polymerase II complex stability.
EMBO J
December 2024
King Abdullah University of Science and Technology, KAUST, Biological and Environmental Sciences and Engineering Division, KAUST Environmental Epigenetics Program, Thuwal, 23955-6900, Kingdom of Saudi Arabia.
Circadian rhythmicity of gene expression is a conserved feature of cell physiology. This involves fine-tuning between transcriptional and post-transcriptional mechanisms and strongly depends on the metabolic state of the cell. Together these processes guarantee an adaptive plasticity of tissue-specific genetic programs.
View Article and Find Full Text PDFResilience to Chronic Stress Is Characterized by Circadian Brain-Liver Coordination.
Biol Psychiatry Glob Open Sci
November 2024
Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California.
Article Synopsis
- Chronic stress disrupts circadian rhythms, which can lead to mental and metabolic health issues; this study investigates how chronic social stress affects the circadian regulation of brain and liver functions in mice.
- Male mice underwent chronic social defeat stress, and their behaviors were analyzed to identify stress resilience and susceptibility, with tissue samples collected for further study every 4 hours.
- Findings suggest that resilient mice exhibit improved circadian transcription patterns and metabolic rhythms across different tissues, indicating better coordination between brain and liver functions compared to those susceptible to stress.
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis.
Cell Stem Cell
June 2024
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain. Electronic address:
In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs.
View Article and Find Full Text PDFBrain-muscle communication prevents muscle aging by maintaining daily physiology.
Science
May 2024
Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock.
View Article and Find Full Text PDFTargeting nuclear receptor corepressors for reversible male contraception.
Proc Natl Acad Sci U S A
February 2024
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
Despite numerous female contraceptive options, nearly half of all pregnancies are unintended. Family planning choices for men are currently limited to unreliable condoms and invasive vasectomies with questionable reversibility. Here, we report the development of an oral contraceptive approach based on transcriptional disruption of cyclical gene expression patterns during spermatogenesis.
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