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The trajectory of serum salicylate concentrations after ingestion of medicinal oil containing methyl salicylate.
Clin Toxicol (Phila)
November 2024
Department of Emergency Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Article Synopsis
- The study investigated how methyl salicylate levels in the blood change after ingestion, aiming to identify peak serum concentrations and factors influencing these levels.
- Researchers analyzed cases from the Hong Kong Poison Control Centre involving 41 patients, finding that the median time to peak concentration was 5.6 hours, with gastric aspiration and activated charcoal use being linked to lower peak levels.
- Results suggest that the peak concentration of serum salicylate occurs slower than previously thought, indicating the need for ongoing monitoring in patients after ingestion.
Liver Cancer Etiology: Old Issues and New Perspectives.
Curr Oncol Rep
November 2024
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Purpose Of Review: This review aims to synthesize the old issues and current understandings of the etiology of liver cancer, focusing on the diverse causative factors influenced by geographical, socioeconomic, and lifestyle variations across different regions.
Recent Findings: We highlight significant geographic disparities in liver cancer risk factors. While hepatitis B and C viruses, aflatoxin exposure, and alcohol consumption remain globally established contributors; metabolic dysfunction-associated steatotic liver disease and metabolic syndromes are increasingly prominent in the West.
Myocardial infarction during treatment of Crotalinae envenomation: A case report.
Toxicon
November 2024
Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.
While myocardial infarction is a rare, but known, potential side effect of snakebite envenomation, snake antivenom has thus far not been associated with any cardiovascular adverse events. We report the case of a 71-year-old man who developed an anterolateral MI during administration of Crotalidae immune F(ab')2 (equine) (ANAVIP), given as treatment for Crotalidae envenomation. The patient required cardiac catheterization with stenting of the left anterior descending artery and was discharged two days later on long-term clopidogrel and aspirin.
View Article and Find Full Text PDFAspirin in the Form of Microneedle Repairs DNA and Reduces Inflammation in Persistent Skin Damage.
Biomater Res
September 2024
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, China.
Article Synopsis
- Skin damage from chemical corrosion, particularly from nitrogen mustard compounds, causes severe issues by damaging DNA, leading to oxidative stress and inflammation.
- Current treatments are ineffective because potential antidotes can't penetrate the skin barrier effectively.
- A new approach using aspirin microneedles aims to directly deliver aspirin to the damaged area, helping reduce inflammation and promote DNA repair, showing promise for wound healing applications.
Pharmacokinetic effects of endoscopic gastric decontamination for multidrug gastric pharmacobezoars.
Toxicol Rep
December 2024
Pediatric Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Introduction: Intentional multiple drugs overdose is an often-encountered method of self-harm in adolescence. Treatments include supportive therapy, antidotes (when available) and decontamination techniques with the aim of reducing drugs absorption by the gastrointestinal system to minimize toxicity. Nevertheless, the decontamination techniques currently used, such as gastric lavage (GL), activated charcoal or whole-bowel irrigation, have a questionable effectiveness.
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