AI Article Synopsis
- The study focused on the effects of proton pencil beam scanning on cytogenetic damage and reactive oxygen species (ROS) in mice after total body irradiation in the Bragg peak dose range of 0.1-1.5 Gy.
- It was conducted at the Prometeus proton synchrotron with protons having energies between 90-116 MeV.
- The results indicated that proton therapy had a relative biological effectiveness (RBE) of 1.15 for cytogenetic changes and showed different impacts on lymphoid organs and ROS production compared to X-ray irradiation.
Article Abstract
The aim of this work was to study the effect of proton pencil beam scanning in the Bragg peak in the dose range of 0.1-1.5 Gy on the induction of cytogenetic damage in the bone marrow, reactive oxygen species (ROS) production in whole blood, and the state of lymphoid organs after total body irradiation of mice. Irradiation was carried out in the Prometeus proton synchrotron (Protvino) in the Bragg peak with proton energy at the output of 90-116 MeV. It was found that, under irradiation of mice in the range of low and medium doses of proton pencil beam scanning in the Bragg peak, the relative biological effectiveness (RBE) according to the criterion of cytogenetic changes was 1.15. In addition, it was found that the pathophysiological effect on the lymphoid organs and the production of ROS by blood cells were different as compared with the effect of X-rays.
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| http://dx.doi.org/10.1134/S1607672920050026 | DOI Listing |
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