Two isopentenyl resorcinols, peperobtusin B and peperobtusin C, have been isolated from . Their structures were determined on the basis of spectroscopic methods, especially H NMR, C NMR, 2D NMR, and HR-TOF-MS. Two compounds were evaluated for cytostatic activity against G, A 549, Hela and HCT 116 cells, but cytostatic activity of both compounds is weak.
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Two isopentenyl resorcinols from .
J Asian Nat Prod Res
September 2021
College of Life Science and Biotechnology, Dalian University, Dalian 116622, China.
Two isopentenyl resorcinols, peperobtusin B and peperobtusin C, have been isolated from . Their structures were determined on the basis of spectroscopic methods, especially H NMR, C NMR, 2D NMR, and HR-TOF-MS. Two compounds were evaluated for cytostatic activity against G, A 549, Hela and HCT 116 cells, but cytostatic activity of both compounds is weak.
View Article and Find Full Text PDFLicocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A.
Chem Biol Interact
January 2020
Wuya College of Innovation, School of Pharmaceutical Engineering, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:
Protein kinases play an indispensable role in signaling pathways that regulate tumor cell functions, which represent potent therapeutic targets in cancers. Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) as a serine/threonine kinase has recently been reported to be upregulated in pancreatic ductal adenocarcinoma (PDAC) and show protumorigenic effect. By activity-guided phytochemical investigation of the extracts from Glycyrrhiza uralensis Fisch, we expect to find the effective constituents that can suppress pancreatic cancer cell proliferation and/or induce cells apoptotic by inhibiting DYRK1A.
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