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| http://dx.doi.org/10.2106/JBJS.OA.20.00058 | DOI Listing |
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Therapeutic role of aripiprazole in cartilage defects explored through a drug repurposing approach.
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Articular cartilage has a limited regenerative capacity, resulting in poor spontaneous healing of damaged tissue. Despite various scientific efforts to enhance cartilage repair, no single method has yielded satisfactory results. With rising drug development costs, drug repositioning has emerged as a viable alternative.
View Article and Find Full Text PDFClinical Application Study of External Fixation Treatment Using Removed Locking Plates in Patients with Failed Debridement and Antimicrobial Therapy for Infection after Internal Fixation of Fractures.
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Department of Orthopedics, No. 2 People's Hospital of Fuyang City, Fuyang City, People's Republic of China.
The main focus of this study is to investigate the clinical efficacy of external fixation treatment using removed locking plates in patients with failed debridement and antimicrobial therapy of infection after internal fixation of fractures. From January 2019 to January 2023, our medical institution treated 13 patients who had failed debridement and antimicrobial therapy for infection after internal fixation of fractures. All patients had their internal fixation devices removed, underwent thorough debridement, and then the removed locking plates were repurposed for external fixation treatment.
View Article and Find Full Text PDFHuman birth tissue products as a non-opioid medicine to inhibit post-surgical pain.
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Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, United States.
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View Article and Find Full Text PDFUnveiling therapeutic targets for spinal stenosis from genetic insights: a Mendelian randomization analysis.
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View Article and Find Full Text PDFPrimary cartilage transcriptional signatures reflect cell-type-specific molecular pathways underpinning osteoarthritis.
Am J Hum Genet
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Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine and Health, 81675 Munich, Germany. Electronic address:
Article Synopsis
- Osteoarthritis research faces challenges due to a lack of understanding of the disease's molecular processes, particularly in cartilage tissue.
- The study reveals significant changes in gene expression related to embryonic development, with differences observed between low- and high-grade osteoarthritis cartilage, indicating distinct cell activity patterns.
- By identifying gene co-expression modules and potential causal genetic variants, the research uncovers new molecular pathways that could serve as potential drug targets for treating osteoarthritis.
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