Invasive aspergillosis (IA) is associated with a high mortality rate in kidney-transplant recipients. Azole-resistance is increasing in . We report a clinical case of a kidney-transplant recipient with cerebellar and pulmonary aspergillosis caused by azole-resistant (molecular identification through β-tubulin sequence). The patient experienced an effective resolution after three surgical procedures and associated antifungal therapy. This case highlights that azole-resistant aspergillosis should be considered in every patient with IA as long as susceptibility testing results are not known. Therefore, in selected patients with IA and central nervous system involvement, empirical combination antifungal therapy could be considered.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582046PMC
http://dx.doi.org/10.1016/j.mmcr.2020.10.001DOI Listing

Publication Analysis

Top Keywords

invasive aspergillosis
8
aspergillosis caused
8
antifungal therapy
8
successful treatment
4
treatment invasive
4
aspergillosis
4
caused kidney
4
kidney transplant
4
transplant recipient
4
recipient invasive
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!