AI Article Synopsis
- The study investigated the effects of nanostructured amorphous silica (SiO) on the immune system of Wistar rats after oral administration, revealing contradictory findings in existing literature.
- Two experiments were conducted, one lasting 92 days with various doses and another lasting 28 days focusing on anaphylactic reactions using a high dose of SiO, assessing various immune and hematological responses.
- Results indicated that while SiO does not worsen anaphylactic reactions, it has toxic effects on T-cells, suggesting a need for regulation of its use in food supplements and additives, with a no observed adverse effect level (NOAEL) established at 100 mg/kg body weight.
Article Abstract
The experimental data on the oral toxicity of nanostructured amorphous silica (SiO), widely used in food supplements, pharmaceuticals, and cosmetics, in terms of its in vivo effect on the immune system, are contradictory. Therefore, this study aimed to assess the rat's immune function after SiO oral administration. In the first experiment, SiO was daily orally administered to Wistar rats for 92 days in doses of 0.1, 1.0, 10, and 100 mg/kg of body weight (bw). In the second 28-day experiment, SiO in a dose of 100 mg/kg bw was daily orally administered to rats parenterally immunized with the food allergen ovalbumin (OVA) for the reproduction of systemic anaphylaxis reaction. Together with integral indices, we assessed intestinal permeability to protein macromolecules; hematology; CD45RA+, CD3+, CD4+, CD8+, and CD161a+ cells; cytokines TNF-α, IL-6, and IL-10; and IgG to OVA. The results obtained showed that SiO has no effect on the severity of the anaphylactic reaction, but is capable inducing a toxic effect on the T-cell immune systems of rats. Estimated no observed adverse effect level NOAEL for SiO ranges up to 100 mg/kg bw in terms of its daily consumption for 1-3 months. Using SiO as a food additive should be the subject of regulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693904 | PMC |
| http://dx.doi.org/10.3390/nano10112126 | DOI Listing |
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