To investigate the surgical therapeutic efficacy of uterine tumors patients underwent Cf-252 neutron intra-cavity and external radiotherapy, and evaluate the application value of Cf-252 neutron radiotherapy. Thirteen cases of uterine tumor with local suspicious lesions or poor prognostic factors after CF-252 neutron intracavity and external radiotherapy were treated with surgery. Among them, 12 cases underwent extrafascial hysterectomy, 1 case underwent extensive hysterectomy and lymphadenectomy. The postoperative pathology and follow-up results were used to evaluate the efficacy. Nine cases showed severe response to radiotherapy in postoperative cervical pathological tissues without residual tumor, and survived for more than 3-14 years, the median survival time was 8 years. All of 4 cases with residual tumor died within 1 year. Delayed healing of vaginal wounds occurred in 3 of the 12 cases. Cf-252 is a good brachytherapy source. The cervical tissue shows severe response to radiotherapy and prolonged healing time of vaginal wound is observed in some cases after CF-252 radiotherapy. To those uterine tumor patients with local suspicious lesions or poor prognostic factors after CF-252 neutron intracavity and external radiotherapy, extrafascial hysterectomy is a safe and feasible treatment method.
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http://dx.doi.org/10.3760/cma.j.cn112152-20190903-00570 | DOI Listing |
Sci Rep
January 2025
Space Science Division, Korea Astronomy and Space Science Institute, Daejeon, 34055, Republic of Korea.
This paper reports the proton response function for solution-grown trans-stilbene scintillator from 1 to 25 MeVee and its application for unfolding neutron spectra of Cf-252 and AmBe sources. Low energy proton response was measured by the Time-of-Flight technique at the Korea Research Institute of Standards and Science. In contrast, high energy response was investigated using a 45 MeV proton beam at the Korea Institute of Radiological & Medical Sciences.
View Article and Find Full Text PDFAppl Radiat Isot
March 2025
Technical Physics Division, Bhabha Atomic Research Centre, Mumbai, India.
This study shows an implementation of neutron-gamma pulse shape discrimination (PSD) using a two-dimensional convolutional neural network. The inputs to the network are snapshots of the unprocessed, digitized signals from a BC501A detector. By exposing a BC501A detector to a Cf-252 source, neutron and gamma signals were collected to create a training dataset.
View Article and Find Full Text PDFObjective: To investigate the therapeutic effect of Cf-252 neutron intracavitary brachytherapy (ICBT) in the treatment of primary vaginal carcinoma of stage I-III, along with advanced complications.
Methods: Between August 2009 and August 2013, 41 patients with intact primary vaginal carcinoma based on the histological diagnosis at the Second Cancer Hospital of Heilongjiang Province (Beidahuang Group General Hospital) and the Daping Hospital of the Third Military Medical University were included in this study. Among them, 32 patients were squamous cell carcinoma, and 9 adenocarcinomas.
Appl Radiat Isot
September 2023
Institute of Nuclear Physics and Chemistry, CAEP, Mianyang, 621900 , China.
A Cf-252 neutron source is widely used for testing and calibrating neutron multiplicity counters. General equations for calculating the time-dependent strength and multiplicity of Cf-252 sources are deduced based upon the decay model of Cf-252, Cf-250, and their daughter products Cm-248 and Cm-246. With the nuclear data of these four nuclides, an instance of a long-aged (>40 a) Cf-252 source is presented to illustrate the variation of the strength and multiplicity with time; the calculation results indicate that the 1st, 2nd, and 3rd moment factorials of the neutron multiplicity are significant decreased compared to the ones of nuclide Cf-252.
View Article and Find Full Text PDFProton therapy enables to deliver highly conformed dose distributions owing to the characteristic Bragg peak and the finite range of protons. However, during proton therapy, secondary neutrons are created, which can travel long distances and deposit dose in out-of-field volumes. This out-of-field absorbed dose needs to be considered for radiation-induced secondary cancers, which are particularly relevant in the case of pediatric treatments.
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