AI Article Synopsis
- LINC00858 has been identified as an oncogene in non-small cell lung cancer, but its role in gastric cancer remains unclear.
- Research demonstrated that LINC00858 is expressed at high levels in gastric cancer tissues compared to normal tissues, confirmed by online data and qRT-PCR.
- Knocking down LINC00858 in gastric cancer cell lines (BGC823 and MGC803) decreased their proliferation and migration, suggesting LINC00858 could be a potential therapeutic target in gastric cancer.
Article Abstract
Previous evidence has shown that the long intergenic non-protein coding RNA 858 (LINC00858) is an oncogene in non-small cell lung cancers. However, the role LINC00858 plays in gastric cancer (GC) is not clear. To illustrate the role LINC00858 plays in GC, the LINC00858 expression in GC and normal tissues was firstly detected. Then, the viability, proliferation and migration of GC BGC823 and MGC803 cells were assessed following LINC00858 knockdown by si-LINC00858 transfection. The results showed that LINC00858 had a high level of expressions in GC tissues as demonstrated by both online data and qRT-PCR assay. Also, the knockdown of LINC00858 reduced the proliferation and migration of BGC823 and MGC803 cells in vitro. Taken together, our data indicate that LINC00858 plays an oncogenic role in GC cells and might act as a potential therapeutic target for GC.
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| http://dx.doi.org/10.5114/pjp.2020.99790 | DOI Listing |
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