Ann Biomed Eng
Escuela Técnica Superior de Ingeniería, Universidad de Sevilla, Avenida Camino de los Descubrimientos s/n, 41092, Seville, Spain.
Published: April 2021
Bone lengthening and bone transport are regeneration processes that commonly rely on distraction osteogenesis, a widely accepted surgical procedure to deal with numerous bony pathologies. Despite the extensive study in the literature of the influence of biomechanical factors, a lack of knowledge about their mechanobiological differences prevents a clinical particularization. Bone lengthening treatments were performed on sheep metatarsus by reproducing the surgical and biomechanical protocol of previous bone transport experiments. Several in vivo monitoring techniques were employed to build an exhaustive comparison: gait analysis, radiographic and CT assessment, force measures through the fixation, or mechanical characterization of the new tissue. A significant initial loss of the bearing capacity, quantified by the ground reaction forces and the limb contact time with the ground, is suffered by the bone lengthening specimens. The potential effects of this anomaly on the musculoskeletal force distribution and the evolution of the bone callus elastic modulus over time are also analyzed. Imaging techniques also seem to reveal lower bone volume in the bone lengthening callus than in the bone transport one, but an equivalent mineralization rate. The simultaneous quantification of biological and mechanical parameters provides valuable information for the daily clinical routine and numerical tools development.
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http://dx.doi.org/10.1007/s10439-020-02665-z | DOI Listing |
Am J Sports Med
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American Hip Institute Research Foundation, Des Plaines, Illinois, USA.
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Department of Surgery, Plastic and Reconstructive Surgical Service, Memorial Sloan Kettering Cancer Center, New York, New York.
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Department of Orthopaedics and Traumatology, Gaziantep University Faculty of Medicine, Gaziantep, TUR.
Distraction osteogenesis is a valuable clinical technique used to address length discrepancies in long bone deformities. This procedure involves performing an osteotomy at an appropriate site in the bone and correcting the deformity through an extension system. This research aims to investigate the efficacy of a newly developed device for use in rat tibias and to provide an alternative to existing devices used in animal experiments.
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Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
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Division of Plastic and Reconstructive Surgery, Children's National Hospital.
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