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Background: The global outbreak of COVID-19, caused by the SARS-CoV-2 virus, has been linked to long-term neurological complications, including Alzheimer's disease (AD) among seniors. However, the precise genetic impact of COVID-19 on long-term AD development remains unclear.
Method: This study leveraged genome-wide association study (GWAS) data and genotype data to explore the genetic correlation between AD and various COVID-19 phenotypes across European ancestry (EA) and African ancestry (AA).
Clinical Manifestations.
Alzheimers Dement
December 2024
1Florida Alzheimer's Disease Research Center, Gainesville, FL, USA.
Background: The use of videoconference platforms for neuropsychological assessment was not as common among mental health practitioners before the COVID-19 pandemic. However, due to lockdowns and quarantines worldwide, mental health professionals had to find a feasible alternative and shift to virtual evaluations. This increased the use of teleneuropsychology in both at a clinical and research level.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Emory University School of Medicine, Atlanta, GA, USA.
Background: African Americans (AA) are disproportionately affected by Long COVID, highlighting the need for targeted research to understand the enduring consequences of COVID-19 within this community. Among the array of symptoms associated with post-acute sequelae of SARS-CoV-2 (PASC), cognitive impairments emerge as a significant concern affecting up to 19% of COVID survivors. In this study, our goal is to comprehensively characterize the specific cognitive domains impacted in older AA adults.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Boston University Alzheimer's Disease Research Center, Boston, MA, USA.
Background: Traumatic encephalopathy syndrome (TES) is the proposed clinical syndrome of chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repetitive head impacts in contact/collision sports. A core clinical feature of TES is cognitive impairment, particularly in memory and executive functions. Cognitive intraindividual variability (IIV) is the extent of variability in neuropsychological test performance (i.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Veterans Affairs Northern California Health Care System, Martinez, CA, USA.
Background: Similar neuroimaging abnormalities are reported in post-COVID patients and patients with AD. Moreover, COVID-19 and Alzheimer's Disease (AD) share genetic vulnerabilities and have similar cognitive symptoms of COVID (e.g.
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