: is the excessive and inadequately justified concern about potential risks of triptans. We evaluated causes and consequences of nonuse of triptans in chronic migraine (CM) : Case-control study. We included CM patients firstly referred to aheadache unit. Patients were cases or controls depending on whether they were triptan naïve, or not. We analyzed if nonuse of triptans was justified by formal contraindications or adverse events. We assessed if triptan naïve patients had higher frequency of vascular risk factors (VRF), contraceptive drugs or older age. : We included 941 patients, 247 (26.2%) triptan users. Triptans had been discontinued due to tolerability in 116 patients (12.3%), being 578 patients (61.4%) triptan naïve. Formal contraindications were found in 23 patients (2.4%). Frequency of VRF, contraceptive drugs or age did not differ between the groups (p > 0.1). Triptan users consumed symptomatic medications fewer days/month (13.9 vs 17.1, p < 0.001), were under prophylactic treatment more frequently (79.4% vs 34.8%, p < 0.001) and had medication overuse headache less frequently (55.1% vs. 63.0%, p = 0.03). : Triptans were not used by three-quartersof CM patients. Nonuse of triptans was not justified by tolerability, frequency of contraindications, or frequency of VRF. : In the present study, we evaluated causes and consequences of the nonuse of triptans in CM sufferers. We analyzed frequency of triptan use in CM patients. We compared, between triptan users and triptan naïve patients, the presence of contraindications, frequency of vascular risk factors, and differences in management prior to the referral to a headache unit.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14737175.2021.1842733 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Use of melatonin supplements and risk of type 2 diabetes and cardiovascular diseases in the USA: insights from three prospective cohort studies.
Lancet Diabetes Endocrinol
June 2024
Department of Nutrition, Harvard T H Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
Background: Use of melatonin supplements has been increasing substantially in both children and adults in the USA; however, their long-term cardiometabolic effects remain unclear. We aimed to assess the associations between regular use of melatonin supplements and the risk of developing type 2 diabetes or cardiovascular disease in adults.
Methods: In this study, we included individuals from three US cohorts: the Nurses' Health Study (women only), the Health Professionals Follow-up Study (men only), and the Nurses' Health Study II (women only).
Genetic and Phenotypic Profiling of Triptan Users in a Swedish Cluster Headache Cohort.
J Mol Neurosci
April 2024
Centre for Cluster Headache, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Article Synopsis
- - Up to 25% of individuals with cluster headache (CH) do not respond well to triptans, the usual first-line treatment, and this study examines the role of genetic variants and clinical characteristics in treatment response.
- - Researchers looked at five genetic variants in a Swedish cohort of 545 CH patients, finding that one variant (rs1024905) was significantly linked to not using triptans, alongside evidence that more 'effector' genetic variants corresponded with lower triptan use.
- - Clinical characteristics revealed that triptan users were more likely to trigger headaches with alcohol, experience autonomic symptoms, and be smokers when compared to non-users, suggesting that certain traits impact the likelihood of using triptans for
The association of melatonin use and hip fracture: a matched cohort study.
Osteoporos Int
June 2023
Department of Orthopedics, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008, Changsha, Hunan, China.
Unlabelled: By using propensity-score matched cohorts, we compared the risk of incident hip fracture between melatonin initiators and hypnotic benzodiazepines initiators. The initiation of melatonin was not associated with an increased risk of hip fracture.
Introduction: Melatonin is hypothesized to suppress bone loss, but a previous study reported an increased risk of hip fracture among melatonin users compared with non-users, which was however susceptible to confounding by indication.
Among psychedelic-experienced users, only past use of psilocybin reliably predicts nature relatedness.
J Psychopharmacol
January 2023
Centre for Psychedelic Research, Imperial College London, London, UK.
Background: Past research reports a positive relationship between experience with classic serotonergic psychedelics and nature relatedness (NR). However, these studies typically do not distinguish between different psychedelic compounds, which have a unique psychopharmacology and may be used in specific contexts and with different intentions. Likewise, it is not clear whether these findings can be attributed to substance use per se or unrelated variables that differentiate psychedelic users from nonusers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!