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Influent, as opposed to activated sludge, is more suitable for SARS-CoV-2 surveillance in wastewater treatment plants.
Water Res
December 2024
Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address:
Wastewater surveillance programs based at wastewater treatment plants (WWTPs) have been widely implemented, becoming a crucial measure for public health. Recently, the scope of monitoring has expanded from influent wastewater to include primary settled solids and activated sludge. The effectiveness of monitoring primary settled solids has been widely validated, but the suitability of activated sludge as a monitoring target remains unclear.
View Article and Find Full Text PDFPolar Networks Mediate Ion Conduction of the SARS-CoV-2 Envelope Protein.
J Am Chem Soc
December 2024
Department of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, Massachusetts 02139, United States.
The SARS-CoV-2 E protein conducts cations across the cell membrane to cause pathogenicity to infected cells. The high-resolution structures of the E transmembrane domain (ETM) in the closed state at neutral pH and in the open state at acidic pH have been determined. However, the ion conduction mechanism remains elusive.
View Article and Find Full Text PDFHumoral and cellular immune response after mRNA SARS-CoV-2 vaccine in children on treatment for cancer: A pilot observational study.
Heliyon
July 2024
Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Immunocompromised children are at risk of developing severe COVID-19 infection. We conducted a pilot prospective study to evaluate the impact of cancer treatment and stem cell transplantation on immunogenicity of two doses of BNT162b2 vaccine in pediatric patients. Humoral, B- and T-cell responses to the BNT162b2 vaccine were assessed before, after the first and the second dose in patients aged 5-12 years (n = 35) and in a group of healthy donors (HD, n = 12).
View Article and Find Full Text PDFIncreased Early-Mortality in Children With Solid Tumors During the COVID-19 Pandemic in a Middle-Income Country.
Cancer Med
December 2024
Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Diego/Rady Children's Hospital San Diego, San Diego, California, USA.
Background: Measures to control COVID-19 transmission disrupted childhood cancer care. Data on the effects of the COVID-19 pandemic on childhood cancer mortality are lacking. This study describes the impact of the pandemic on childhood cancer early-mortality (≤ 24 months).
View Article and Find Full Text PDFZn inhibits PEDV replication by inducing autophagy through the Akt-mTOR pathway.
Vet Microbiol
December 2024
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China. Electronic address:
Porcine epidemic diarrhea virus (PEDV) is a coronavirus that induces diarrhea in pigs, leading to severe economic losses in the global pig industry. Currently, effective antiviral treatments for porcine epidemic diarrhea (PED) are rarely available for clinical use. Zinc (Zn), an essential mineral, is known to reduce diarrhea in piglets transitioning from milk to solid feed by modulating immune system activity.
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