AI Article Synopsis
- Spirocyclopropane is a unique chemical structure that helps create a variety of complex spirocarbo- and heterocyclic compounds used in drugs and natural products.
- Recent advancements focus on synthetic methods that break carbon-carbon bonds in spirocyclopropanes to efficiently create these compounds.
- The paper reviews new techniques for selectively expanding the rings of spirocyclopropanes and discusses their relevance in synthesizing biologically active natural products.
Article Abstract
Spirocyclopropane represents a privileged structural scaffold for accessing synthetic libraries of densely functionalized spirocarbo- and heterocyclic compounds. Due to the ubiquity of spirocyclic motifs as a potent pharmacophore in natural products and pharmaceuticals, recent years have witnessed significant advances in developing synthetic strategies that exploits carbon-carbon bond scission in spirocyclopropanes. This paper summarizes the recent developments in stereoselective ring expansion of spirocyclopropanes in diversity-oriented synthesis and highlights the synthetic as well as mechanistic rationale of those methodologies. This review also encompasses the applicability of the protocols in bioactive natural product syntheses.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581100 | PMC |
| http://dx.doi.org/10.1021/acsomega.0c03856 | DOI Listing |
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