Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of chronic liver disease associated with organ failures. Anemia of diverse etiology is common in patients with ACLF. Spur cell anemia (SCA) is a form of acquired hemolytic anemia that occurs rarely in such patients due to dysregulated lipids metabolism. Spur cells are large erythrocytes with spike-like projections, which predispose them for sequestration and destruction in splenic canaliculi. There is a paucity of data on SCA in patients with ACLF. Here we report a series of five ACLF patients who had severe (hemoglobin level < 8 g/dL) and transfusion-refractory SCA with aggressive clinical course and high mortality rate.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579423 | PMC |
| http://dx.doi.org/10.7759/cureus.10568 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit.
Nat Commun
January 2025
Neuronal Cell Biology Division, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38104, USA.
Exiting a germinal zone (GZ) initiates a cascade of events that promote neuronal maturation and circuit assembly. Developing neurons and their progenitors must interpret various niche signals-such as morphogens, guidance molecules, extracellular matrix components, and adhesive cues-to navigate this region. How differentiating neurons in mouse brains integrate and adapt to multiple cell-extrinsic niche cues with their cell-intrinsic machinery in exiting a GZ is unknown.
View Article and Find Full Text PDFDesigning Current Collectors to Stabilize Li Metal Anodes.
Adv Mater
January 2025
Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University, Tianjin, 300071, China.
Rechargeable batteries employing Li metal anodes have gained increasing attention due to their high energy density. Nevertheless, low stability and reversibility of Li metal anodes severely impeded their practical applications. Designing current collectors (CCs) with reasonable structure and composition is an efficient approach to stabilizing the Li metal anodes.
View Article and Find Full Text PDFFlexible silicon for high-performance photovoltaics, photodetectors and bio-interfaced electronics.
Mater Horiz
December 2024
School of Electronics Science and Engineering, Nanjing University, 210023 Nanjing, P. R. China.
Silicon (Si) is currently the most mature and reliable semiconductor material in the industry, playing a pivotal role in the development of modern microelectronics, renewable energy, and bio-electronic technologies. In recent years, widespread research attention has been devoted to the development of advanced flexible electronics, photovoltaics, and bio-interfaced sensors/detectors, boosting their emerging applications in distributed energy sources, healthcare, environmental monitoring, and brain-computer interfaces (BCIs). Despite the rigid and brittle nature of Si, a series of new fabrication technologies and integration strategies have been developed to enable a wide range of c-Si-based high-performance flexible photovoltaics and electronics, which were previously only achievable with intrinsically soft organic and polymer semiconductors.
View Article and Find Full Text PDFDual BACH1 regulation by complementary SCF-type E3 ligases.
Cell
December 2024
Discovery Sciences, Novartis Biomedical Research, Basel, Switzerland. Electronic address:
Broad-complex, tramtrack, and bric-à-brac domain (BTB) and CNC homolog 1 (BACH1) is a key regulator of the cellular oxidative stress response and an oncogene that undergoes tight post-translational control by two distinct F-box ubiquitin ligases, SCF and SCF. However, how both ligases recognize BACH1 under oxidative stress is unclear. In our study, we elucidate the mechanism by which FBXO22 recognizes a quaternary degron in a domain-swapped β-sheet of the BACH1 BTB dimer.
View Article and Find Full Text PDFSpermatogenesis and sperm ultrastructure of the squid, Todarodes pacificus (Cephalopoda: Ommastrephidae).
Micron
February 2025
Department of Aqualife Medicine, Chonnam National University, Yeosu 59626, Republic of Korea. Electronic address:
Article Synopsis
- - The study focuses on spermatogenesis in Todarodes pacificus, identifying four stages: spermatogonium, spermatocyte, spermatid, and mature sperm.
- - Key characteristics of each stage are noted, including changes in karyoplasm and the development of structures such as mitochondria and proacrosomal vesicles during spermiogenesis.
- - Mature sperm are detailed with a specific nucleus size, irregular karyoplasm shape, and distinct acrosome and flagellum structures essential for function.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!