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Toward Long-Life High-Voltage Aqueous Li-Ion Batteries: from Solvation Chemistry to Solid-Electrolyte-Interphase Layer Optimization Against Electron Tunneling Effect.
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Department of Chemistry, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Republic of Korea.
Water is pursued as an electrolyte solvent for its non-flammable nature compared to traditional organic solvents, yet its narrow electrochemical stability window (ESW) limits its performance. Solvation chemistry design is widely adopted as the key to suppress the reactivity of water, thereby expanding the ESW. In this study, an acetamide-based ternary eutectic electrolyte achieved an ESW ranging from 1.
View Article and Find Full Text PDFNGS Detects Extensive Genomic Alterations in Survivors of Irradiated Normal Human Fibroblast Cells.
Radiat Res
December 2024
Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany.
It is thought that cells surviving ionizing radiation exposure repair DNA double-strand breaks (DSBs) and restore their genomes. However, the recent biochemical and genetic characterization of DSB repair pathways reveals that only homologous recombination (HR) can function in an error-free manner and that the non-homologous end joining (NHEJ) pathways canonical NHEJ (c-NHEJ), alternative end joining (alt-EJ), and single-strand annealing (SSA) are error-prone, and potentially leave behind genomic scars and altered genomes. The strong cell cycle restriction of HR to S/G2 phases and the unparalleled efficiency of c-NHEJ throughout the cell cycle, raise the intriguing question as to how far a surviving cell "reaches" after repairing the genome back to its pre-irradiation state.
View Article and Find Full Text PDFAmelioration of signaling deficits underlying metabolic shortfall in TREM2 human iPSC-derived microglia.
FEBS J
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Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, UK.
The microglial triggering receptor expressed on myeloid cells 2 (TREM2) is required for diverse microglia responses in neurodegeneration, including immunometabolic plasticity, phagocytosis, and survival. We previously identified that patient iPSC-derived microglia (iPS-Mg) harboring the Alzheimer's disease (AD) TREM2 hypomorph display several functional deficits linked to metabolism. To investigate whether these deficits are associated with disruptions in metabolite signaling, we generated common variant, TREM2 and TREM2 variant human iPS-Mg.
View Article and Find Full Text PDFRegulation of pathway choice in DNA repair after double-strand breaks.
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Biotechnology Research and Innovation Council - National Institute of Immunology (BRIC-NII), Aruna Asaf Ali Marg, New Delhi 110067, India; Biotechnology Research and Innovation Council - National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani 741251, India. Electronic address:
DNA damage signaling is a highly coordinated cellular process which is required for the removal of DNA lesions. Amongst the different types of DNA damage, double-strand breaks (DSBs) are the most harmful type of lesion that attenuates cellular proliferation. DSBs are repaired by two major pathways-homologous recombination (HR), and non-homologous end-joining (NHEJ) and in some cases by microhomology-mediated end-joining (MMEJ).
View Article and Find Full Text PDFAnalysis of the dynamic evolution of green technology innovation decision-making in the supply chain.
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School of Business Administration, Chongqing Vocational College of Light Industry, Chongqing, 400065, China. Electronic address:
Green technology innovation (GTI) breaks the vicious cycle of "economic development-environmental pollution," mitigating the supply chain carbon emissions. Previous research focused on exploring supply chain GTI decision-making in the discrete strategy space and ignored the effect of stochastic factors. This paper, grounded in the classical evolutionary game theory, explores the interaction mechanism of supply chain GTI decision-making between suppliers and manufacturers under stochastic interferences and in the continuous strategy space.
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