Adenomatoid Odontogenic Tumor (AOT) is a benign, non-invasive tumor with slow but progressive growth, mainly affecting younger patients, predominantly females. It is more often located in maxilla, involving an unerupted or erupted tooth, mostly canine. There are three variants, namely follicular, extra-follicular and peripheral. Permanent cuspids account for 60% of all follicular and 89% of all extra-follicular AOT. This article discusses a unique case of extra-follicular AOT in 9 year old male patient associated with partially erupted maxillary central incisor.
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| http://dx.doi.org/10.4103/ccd.ccd_344_20 | DOI Listing |
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Extrafollicular Adenomatoid Odontogenic Tumors: A Series of Five Rare Cases with an Insight into Its Clinicopathological Aspects.
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Department of Oral Pathology, Dr. R Ahmed Dental College, Kolkata, West Bengal, India.
Adenomatoid odontogenic tumors (AOT), first described by Steensland in 1905, are benign, slowly enlarging, nonaggressive, odontogenic epithelial neoplasms comprising 3%-7% of all odontogenic tumors. They tend to originate from the dental lamina remnants or the reduced enamel epithelium. Mutation at codon 12 of KRAS oncogene (Kirsten rat sarcoma viral oncogene homolog) plays a pivotal role in the pathogenesis.
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Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Bangkok, Thailand.
Objectives: Histone modification in odontogenic lesions is mostly unexplored. Trimethylation of histone H3 at lysine residue 9 (H3K9Me3) has been studied in various pathologic conditions and showed biological significance promising for future therapeutic application. This study aimed to investigate the level and clinical relevance of the H3K9Me3 histone modification in odontogenic cysts and tumors.
View Article and Find Full Text PDFChanging Trends of Odontogenic Cysts and Tumors in Kenya: A 20-Year Retrospective Analysis.
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Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, MYS.
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Immunohistochemical Evaluation of p300, H2AacK5 and H3AcK27 in Odontogenic Cysts and Tumors.
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Cell Culture Laboratory, School of Dentistry, Federal University of Pará, Belém, Brazil.
The acetylation of histones H2A on lysine 5 (H2AacK5) and H3 on lysine 27 (H3AcK27) modulate several cellular mechanisms through the p300 enzyme in pathological lesions; however, their role in odontogenic lesions has not been addressed. This study aims to evaluate the immunoexpression of p300, H2AacK5, and H3AcK27 in samples of ameloblastoma (AMB) (n = 30), odontogenic keratocyst (OK) (n = 15), adenomatoid odontogenic tumor (AOT) (n = 10), odontogenic fibroma (OF) (n = 8), calcifying odontogenic cyst (COC) (n = 8), odontogenic myxoma (MIX) (n = 10), and ameloblastic fibroma (AF) (n = 06). The percentage of p300-positive cells was higher in AOT and decreased in COC, OK, AMB, AF, OF, and MIX.
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Article Synopsis
- Adenoid ameloblastoma (AA) is a rare but locally aggressive benign tumor derived from dental tissue remnants, and it was recently classified as a new type of odontogenic lesion by the WHO in 2022.
- This tumor behaves more aggressively than similar types, presenting as a painless jaw swelling with a high recurrence rate and local invasiveness, and exhibits unique histopathological features such as a cribriform pattern and differential marker expression.
- Due to its complex nature and unclear origins, AA requires thorough clinical evaluation and customized treatment approaches to manage recurrence and improve patient outcomes, with the latest research contributing to its understanding post-classification.
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