Snow avalanche is among the most harmful natural hazards with major socioeconomic and environmental destruction in the cold and mountainous regions. The devastating propagation and accumulation of the snow avalanche debris and mass wasting of surface rocks and vegetation particles threaten human life, transportation networks, built environments, ecosystems, and water resources. Susceptibility assessment of snow avalanche hazardous areas is of utmost importance for mitigation and development of land-use policies. This research evaluates the performance of the well-known machine learning methods, i.e., generalized additive model (GAM), multivariate adaptive regression spline (MARS), boosted regression trees (BRT), and support vector machine (SVM), in modeling the mass wasting hazard induced by snow avalanches. The key features are identified by the recursive feature elimination (RFE) method and used for the model calibration. The results indicated a good performance of the modeling process (Accuracy > 0.88, Kappa > 0.76, Precision > 0.84, Recall > 0.86, and AUC > 0.89), which the SVM model highlighted superior performance than others. Sensitivity analysis demonstrated that the topographic position index (TPI) and distance to stream (DTS) were the most important variables which had more contribution in producing the susceptibility maps.
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http://dx.doi.org/10.1038/s41598-020-75476-w | DOI Listing |
J Comp Pathol
January 2025
Department of Pathobiology and Population Medicine, Mississippi State University, 240 Wise Center Drive, Mississippi State, Mississippi 39762, USA.
Histoplasmosis is a rarely reported clinical disease of equids in North America and is historically attributed to Histoplasma capsulatum var. capsulatum. This report details a case of intestinal histoplasmosis with lymphadenitis in an American Mammoth Jackstock donkey from Mississippi.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037-1002.
Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional status; however, the detailed mechanisms remain to be fully elucidated. Here, we show that the transcriptional repressor B cell lymphoma 6 (BCL6) maintains muscle mass by sustaining GH action.
View Article and Find Full Text PDFFront Nutr
January 2025
Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University and Beijing Tuberculosis and Tumor Research Institute, Beijing, China.
Background: As a state of metabolic and nutritional derangements, protein-energy wasting (PEW) is highly prevalent and associated with increased morbidity and mortality in hemodialysis patients. Fibroblast growth factor-23 (FGF-23) and Klotho have been proven to contribute to chronic kidney disease-mineral and bone disorder (CKD-MBD) in patients undergoing hemodialysis. Previous evidence suggested that FGF-23 and Klotho may also contribute to the malnutritional status among these patients; however, the inter-relationship between the FGF-23-Klotho axis and PEW remains unclear.
View Article and Find Full Text PDFERJ Open Res
January 2025
Faculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle upon Tyne, UK.
Background: In response to exercise-based pulmonary rehabilitation (PR), the type of muscle fibre remodelling differs between COPD patients with peripheral muscle wasting (atrophic patients with COPD) and those without wasting (nonatrophic patients with COPD). Extracellular matrix (ECM) proteins are major constituents of the cell micro-environment steering cell behaviour and regeneration. We investigated whether the composition of ECM in atrophic compared to nonatrophic patients with COPD differs in response to PR.
View Article and Find Full Text PDFAIDS Care
January 2025
Physical Activity, Lifestyle, Ageing and Wellbeing Faculty Research Group, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Exercise is vital in managing sarcopenia in people living with HIV (PLWH). This study explores the role of exercise in reducing sarcopenia in HIV patients. A systematic search of electronic databases including PubMed, Scopus, and Web of Science identifed relevant articles published in English up to April 2024.
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