AI Article Synopsis
- The study analyzed severe toxicity in lung cancer patients undergoing chemotherapy, focusing on when these toxic effects occurred.
- Out of 569 patients, 76.1% experienced severe toxicity, with the majority occurring after the first chemotherapy session.
- Factors like performance status and treatment type were found to predict the likelihood of severe toxicity, highlighting the need to consider timing in future research.
Article Abstract
Background/aim: The aim of this study was to investigate the timing of severe toxicity in lung cancer patients receiving chemotherapy.
Patients And Methods: Patients with advanced non-small cell lung cancer or limited disease small cell lung cancer included in two randomized controlled trials were analysed. Severe toxicity was defined as grade 3-5 toxicity according to the Common Terminology Criteria for Adverse Events (CTCAE) v3.0.
Results: We analysed 569 patients and 433 (76.1%) experienced severe toxicity. Of these, 249 (57.5%) experienced the first episode of severe toxicity after the first, 109 (25.2%) after the second, 54 (12.5%) after the third and 18 (4.2%) after the fourth course of chemotherapy. Performance status (PS 2 vs. 0-1; p=0.046) and treatment arm were independent predictive factors for severe toxicity.
Conclusion: Severe toxicity was most frequent after the first chemotherapy course, but some patients did not experience severe toxicity until after the fourth course. Accounting for timing might be important when studying factors predicting severe toxicity.
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| http://dx.doi.org/10.21873/anticanres.14661 | DOI Listing |
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